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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Vascular endothelial growth factor overexpression in induced sputum of children with bronchial asthma
Pediatric Allergy and Immunology, Volume 20, No. 1, Year 2009
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Description
Vascular endothelial growth factor (VEGF) induces angiogenesis and increases vascular permeability participating in narrowing of the airway lumen that follows lung injury. We sought to investigate the expression of VEGF in induced sputum during and after recovery from acute episodes of bronchial asthma in children. Eighteen asthmatic children with acute attacks of varying severity were subjected to VEGF estimation by an enzymatic immunoassay in induced sputum. They were followed up till complete remission of symptoms and signs and were then retested. VEGF was also estimated in sputum induced from age 34 and sex-matched healthy children enrolled as a control group. The sputum VEGF levels during acute asthma [median = 71 ng/ml; mean (s.d.) = 114.6 (121.8) ng/ml] were significantly higher than the levels estimated during remission [median = 50 ng/ml; mean (s.d.) = 45.7 (24.2) ng/ml] and both were higher than the corresponding levels of the control group [median = 36 ng/ml; mean (s.d.) = 31.3 (17.2) ng/ml]. VEGF levels during asthmatic episodes correlated positively to the recovery levels (r = 0.6, p = 0.009). The patients' VEGF expression did not vary with asthma severity, serum total IgE concentration, peripheral blood eosinophil count, or erythrocyte sedimentation rate of patients. Children on corticosteroids inhalation therapy at enrollment had sputum VEGF levels that were comparable to those on other therapies. The increased expression of sputum VEGF in asthmatic children reinforces the concept that it might have a pathogenetic role in bronchial asthma and may represent a biomarker of airway inflammation. © 2008 Blackwell Munksgaard.
Authors & Co-Authors
Hossny, Elham
Egypt, Cairo
Ain Shams University
El-Awady, H.
Egypt, Cairo
Ain Shams University
Bakr, Salwa Ibrahim
Egypt, Cairo
Ain Shams University
Labib, A.
Egypt, Cairo
Ain Shams University
Statistics
Citations: 28
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1111/j.1399-3038.2008.00730.x
ISSN:
09056157
e-ISSN:
13993038
Research Areas
Cancer
Maternal And Child Health
Violence And Injury
Study Design
Randomised Control Trial