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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal
PLoS ONE, Volume 3, No. 4, Article e2000, Year 2008
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Description
Plasmodium falciparum malaria episodes may vary considerably in their severity and clinical manifestations. There is good evidence that host genetic factors contribute to this variability. To date, most genetic studies aiming at the identification of these genes have used a case/ control study design for severe malaria, exploring specific candidate genes. Here, we performed a family-based genetic study of falciparum malaria related phenotypes in two independent longitudinal survey cohorts, as a first step towards the identification of genes and mechanisms involved in the outcome of infection. We studied two Senegalese villages, Dielmo and Ndiop that differ in ethnicity, malaria transmission and endemicity. We performed genome-scan linkage analysis of several malaria-related phenotypes both during clinical attacks and asymptomatic infection. We show evidence for a strong genetic contribution to both the number of clinical falciparum malaria attacks and the asymptomatic parasite density. The asymptomatic parasite density showed linkage to chromosome 5q31 (LOD = 2.26, empirical p = 0.0014, Dielmo), confirming previous findings in other studies. Suggestive linkage values were also obtained at three additional chromosome regions: the number of clinical malaria attacks on chromosome 5p15 (LOD = 2.57, empirical p = 0.001, Dielmo) and 13q13 (LOD = 2.37, empirical p = 0.0014 Dielmo), and the maximum parasite density during asymptomatic infection on chromosome 12q21 (LOD = 3.1, empirical p<10-4, Ndiop). While regions of linkage show little overlap with genes known to be involved in severe malaria, the four regions appear to overlap with regions linked to asthma or atopy related traits, suggesting that common immune related pathways may be involved. © 2008 Sakuntabhai et al.
Authors & Co-Authors
Sakuntabhai, Anavaj
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Ndiaye Diallo, Rokhaya
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Senegal, Dakar
Institut Pasteur de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Casadémont, Isabelle
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Peerapittayamonkol, Chayanon
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Thailand, Bangkok
Faculty of Medicine Siriraj Hospital, Mahidol University
Rogier, Christophe
Senegal, Dakar
Institut Pasteur de Dakar
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Tortevoye, Patricia
France, Paris
Institut Pasteur, Paris
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Paul, Richard P.C.
France, Paris
Institut Pasteur, Paris
Turbpaiboon, Chairat
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Thailand, Nakhon Pathom
Mahidol University
Phimpraphi, Waraphon
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Spiegel, André
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
École du Val-de-grâce
Heath, Simon C.
France, Evry
Centre National de Recherche en Génomique Humaine
Mercereau-Puijalon, Odile
France, Paris
Cnrs Centre National de la Recherche Scientifique
Diéye, Alioune M.
Senegal, Dakar
Institut Pasteur de Dakar
Julier, Cécile
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
France, Evry
Centre National de Recherche en Génomique Humaine
Statistics
Citations: 58
Authors: 16
Affiliations: 11
Identifiers
Doi:
10.1371/journal.pone.0002000
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal