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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV controllers are distinguished by chemokine expression profile and HIV-specific T-cell proliferative potential
Journal of Acquired Immune Deficiency Syndromes, Volume 59, No. 5, Year 2012
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Description
Background: HIV controllers demonstrate a natural ability to control HIV replication in the absence of antiretroviral therapy. We performed a comprehensive evaluation of inflammation and T-cell activation in a demographically unique cohort of HIV controllers and noncontrollers. Methods: Plasma concentrations of 22 cytokines and chemokines were evaluated using a multiplex bead array approach. Multicolor flow cytometry was used to measure baseline levels of T-cell activation and regulatory T cells (Tregs) and HIV-specific T-cell cytokine (interferon g, interleukin 2) and proliferation responses. Results: HIV controllers were characterized by elevated macrophage inflammatory protein 1α and low levels of interferon γ-induced protein 10, monocyte chemotactic protein 1, and Transforming growth factor beta. Activated (CD38 + HLA DR +) CD4 + and CD8 + T cells were reduced in HIV controllers relative to noncontrollers. HIV controllers and noncontrollers had comparable proportions of Tregs within the CD4 + T-cell compartment, but absolute Treg counts were depleted in noncontrollers. Absolute Treg counts correlated inversely with T-cell activation. Proliferative CD4 + and CD8 + T-cell responses directed against HIV gag epitopes were found most frequently among HIV controllers with the lowest viral loads (elite controllers) and were rarely detected among noncontrollers, supporting a relationship between HIV-specific T-cell proliferation and viral control. Conclusions: Collectively, these data suggest a model in which HIV controllers maintain low levels of viral replication through robust HIV-specific T-cell responses in an environment of low inflammation and reduced availability of activated target cells. © 2012 Lippincott Williams &Wilkins.
Authors & Co-Authors
Card, Catherine M.
Canada, Winnipeg
University of Manitoba
Keynan, Y.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Lajoie, Julie
Canada, Winnipeg
University of Manitoba
Bell, Courtney P.
Canada, Winnipeg
University of Manitoba
Dawood, Magdy
Canada, Winnipeg
University of Manitoba
Canada, Winnipeg
Cadham Provincial Laboratory
Becker, Marissa L.
Canada, Winnipeg
University of Manitoba
Kasper, Ken
Canada, Winnipeg
University of Manitoba
Fowke, Keith Raymond
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 34
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e3182454fcd
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cohort Study