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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Impact of second-line antiretroviral regimens on lipid profiles in an African setting: The DART trial sub-study
AIDS Research and Therapy, Volume 11, No. 1, Article 32, Year 2014
Notification
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Description
Background: Increasing numbers of HIV-infected patients in sub-Saharan Africa are exposed to antiretroviral therapy (ART), but there are few data on lipid changes on first-line ART, and even fewer on second-line.Methods: DART was a randomized trial comparing monitoring strategies in Ugandan/Zimbabwean adults initiating first-line ART and switching to second-line at clinical/immunological failure. We evaluated fasting lipid profiles at second-line initiation and ≥48 weeks subsequently in stored samples from Zimbabwean patients switching before 18 September 2006.Results: Of 91 patients switched to second-line ART, 65(73%) had fasting samples at switch and ≥48 weeks, 14(15%) died or were lost <48 weeks, 10(11%) interrupted ART for >14 days and 2(2%) had no samples available. 56/65(86%) received ZDV/d4T + 3TC + TDF first-line, 6(9%) ZDV/d4T + 3TC + NVP and 3(5%) ZDV + 3TC with TDF and NVP. Initial second-line regimens were LPV/r + NNRTI in 27(41%), LPV/r + NNRTI + ddI in 33(50%) and LPV/r + TDF + ddI/3TC/ZDV in 6(9%). At second-line initiation median (IQR) TC, LDL-C, HDL-C and TG (mmol/L) were 3.3(2.8-4.0), 1.7(1.3-2.2), 0.7(0.6-0.9) and 1.1(0.8-1.9) respectively. Levels were significantly increased 48 weeks later, by mean (SE) +2.0(0.1), +1.1(0.1), +0.5(0.05) and +0.4(0.2) respectively (p < 0.001; TG p = 0.01). 3% at switch vs 25% 48 weeks later had TC >5.2 mmol/L; 3% vs 25% LDL-C >3.4 mmol/L and 91% vs 41% HDL-C <1.1 mmol/L (p < 0.001). Similar proportions had TG >1.8 mmol/L (0 vs 3%) and TC/HDL-C ≥5 (40% vs 33%) (p > 0.15).Conclusion: Modest lipid elevations were observed in African patients on predominantly LPV/r + NNRTI-based second-line regimens. Routine lipid monitoring during second-line ART regimens may not be warranted in this setting but individual cardiovascular risk assessment should guide practice. © 2014 Gomo et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Gomo, Zvenyika Alfred R.
Zimbabwe, Harare
University of Zimbabwe
Hakim, James Gita
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Zimbabwe, Harare
University of Zimbabwe
Walker, Sarah A.S.
United Kingdom, London
Mrc Clinical Trials Unit
Tinago, Willard
Zimbabwe, Harare
University of Zimbabwe
Mandozana, Gibson
Zimbabwe, Harare
University of Zimbabwe
Kityo, Cissy Mutuluuza
Uganda, Kampala
Joint Clinical Research Center Uganda
Munderi, Paula
Uganda, Entebbe
Uganda Virus Research Institute
United Kingdom, London
Medical Research Council
Katabira, Elly Tebasoboke
Uganda, Kampala
Joint Clinical Research Center Uganda
Uganda, Kampala
Mulago Hospital
Uganda, Kampala
Makerere University
Reid, Andrew
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Zimbabwe, Harare
University of Zimbabwe
Gibb, Diana M.
United Kingdom, London
Mrc Clinical Trials Unit
Gilks, Charles F.
United Kingdom, London
Imperial College London
Grosskurth, Heiner
United Kingdom, London
Medical Research Council
Kabuye, Geoffrey
United Kingdom, London
Medical Research Council
Nsibambi, D.
United Kingdom, London
Medical Research Council
Kasirye, Ronnie P.
United Kingdom, London
Medical Research Council
Zalwango, Eva
United Kingdom, London
Medical Research Council
Nakazibwe, M.
United Kingdom, London
Medical Research Council
Kikaire, Bernard
United Kingdom, London
Medical Research Council
Nassuna, Gladys
United Kingdom, London
Medical Research Council
Massa, Rosemary
United Kingdom, London
Medical Research Council
Fadhiru, K.
United Kingdom, London
Medical Research Council
Namyalo, M.
United Kingdom, London
Medical Research Council
Zalwango, Aisha
United Kingdom, London
Medical Research Council
Generous, Lillian
United Kingdom, London
Medical Research Council
Khauka, P.
United Kingdom, London
Medical Research Council
Rutikarayo, N.
United Kingdom, London
Medical Research Council
Nakahima, William
United Kingdom, London
Medical Research Council
Mugisha, Annet
United Kingdom, London
Medical Research Council
Todd, Jim E.
United Kingdom, London
Medical Research Council
Levin, Jonathan B.
United Kingdom, London
Medical Research Council
Muyingo, Sylvia Kiwuwa
United Kingdom, London
Medical Research Council
Ruberantwari, Anthony
United Kingdom, London
Medical Research Council
Kaleebu, Pontiano
United Kingdom, London
Medical Research Council
Yirrell, David L.
United Kingdom, London
Medical Research Council
Ndembi, Nicaise N.
United Kingdom, London
Medical Research Council
Lyagoba, F.
United Kingdom, London
Medical Research Council
Hughes, Peter
United Kingdom, London
Medical Research Council
Aber, M.
United Kingdom, London
Medical Research Council
Medina-Lara, Antonieta
United Kingdom, London
Medical Research Council
Medina, A.
United Kingdom, London
Medical Research Council
Foster, Stephanie L.
United Kingdom, London
Medical Research Council
Amurwon, Jovita
United Kingdom, London
Medical Research Council
Wakholi, Barbara Nyanzi
United Kingdom, London
Medical Research Council
Nyanzi, B.
United Kingdom, London
Medical Research Council
Wangati, K.
United Kingdom, London
Medical Research Council
Amuron, Barbara
United Kingdom, London
Medical Research Council
Kajungu, Dan K.
United Kingdom, London
Medical Research Council
Nakiyingi, Jessica S.
United Kingdom, London
Medical Research Council
Omony, W.
United Kingdom, London
Medical Research Council
Mugyenyi, Peter N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Ssali, Francis N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Tumukunde, Dinah
Uganda, Kampala
Joint Clinical Research Center Uganda
Otim, T.
Uganda, Kampala
Joint Clinical Research Center Uganda
Kabanda, J.
Uganda, Kampala
Joint Clinical Research Center Uganda
Musana, Hellen Wambongo
Uganda, Kampala
Joint Clinical Research Center Uganda
Akao, Juliette N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Kyomugisha, Hope
Uganda, Kampala
Joint Clinical Research Center Uganda
Byamukama, Adolf
Uganda, Kampala
Joint Clinical Research Center Uganda
Sabiiti, Jesca Nsungwa
Uganda, Kampala
Joint Clinical Research Center Uganda
Komugyena, J.
Uganda, Kampala
Joint Clinical Research Center Uganda
Wavamunno, Priscilla
Uganda, Kampala
Joint Clinical Research Center Uganda
Mukiibi, S.
Uganda, Kampala
Joint Clinical Research Center Uganda
Drasiku, Amos
Uganda, Kampala
Joint Clinical Research Center Uganda
Byaruhanga, Rose
Uganda, Kampala
Joint Clinical Research Center Uganda
Labeja, O.
Uganda, Kampala
Joint Clinical Research Center Uganda
Katundu, Pauline
Uganda, Kampala
Joint Clinical Research Center Uganda
Tugume, Sitefano Buguruka
Uganda, Kampala
Joint Clinical Research Center Uganda
Awio, Peter
Uganda, Kampala
Joint Clinical Research Center Uganda
Namazzi, A.
Uganda, Kampala
Joint Clinical Research Center Uganda
Bakeinyaga, G. T.
Uganda, Kampala
Joint Clinical Research Center Uganda
Abaine, D.
Uganda, Kampala
Joint Clinical Research Center Uganda
Tukamushaba, J.
Uganda, Kampala
Joint Clinical Research Center Uganda
Anywar, W.
Uganda, Kampala
Joint Clinical Research Center Uganda
Ojiambo, W.
Uganda, Kampala
Joint Clinical Research Center Uganda
Angweng, E.
Uganda, Kampala
Joint Clinical Research Center Uganda
Murungi, S.
Uganda, Kampala
Joint Clinical Research Center Uganda
Haguma, W.
Uganda, Kampala
Joint Clinical Research Center Uganda
Atwiine, Simon Peter
Uganda, Kampala
Joint Clinical Research Center Uganda
Kigozi, Jesse
Uganda, Kampala
Joint Clinical Research Center Uganda
Namale, Letitia
Uganda, Kampala
Joint Clinical Research Center Uganda
Mukose, Aggrey David
Uganda, Kampala
Joint Clinical Research Center Uganda
Mulindwa, Gertrude Kayaga
Uganda, Kampala
Joint Clinical Research Center Uganda
Atwiine, Diana
Uganda, Kampala
Joint Clinical Research Center Uganda
Muhwezi, Allan
Uganda, Kampala
Joint Clinical Research Center Uganda
Nimwesiga, E.
Uganda, Kampala
Joint Clinical Research Center Uganda
Barungi, G.
Uganda, Kampala
Joint Clinical Research Center Uganda
Takubwa, J.
Uganda, Kampala
Joint Clinical Research Center Uganda
Mwebesa, D.
Uganda, Kampala
Joint Clinical Research Center Uganda
Kagina, G.
Uganda, Kampala
Joint Clinical Research Center Uganda
Mulindwa, M.
Uganda, Kampala
Joint Clinical Research Center Uganda
Ahimbisibwe, Fred
Uganda, Kampala
Joint Clinical Research Center Uganda
Mwesigwa, Phyllis
Uganda, Kampala
Joint Clinical Research Center Uganda
Akuma, Sophie H.
Uganda, Kampala
Joint Clinical Research Center Uganda
Zawedde, C.
Uganda, Kampala
Joint Clinical Research Center Uganda
Nyiraguhirwa, D.
Uganda, Kampala
Joint Clinical Research Center Uganda
Tumusiime, C. S.
Uganda, Kampala
Joint Clinical Research Center Uganda
Bagaya, L.
Uganda, Kampala
Joint Clinical Research Center Uganda
Namara, W.
Uganda, Kampala
Joint Clinical Research Center Uganda
Karungi, J.
Uganda, Kampala
Joint Clinical Research Center Uganda
Kankunda, R.
Uganda, Kampala
Joint Clinical Research Center Uganda
Latif, Ahamed S.
Zimbabwe, Harare
University of Zimbabwe
Robertson, Valerie J.
Zimbabwe, Harare
University of Zimbabwe
Chidziva, Ennie
Zimbabwe, Harare
University of Zimbabwe
Bulaya-Tembo, Ruth
Zimbabwe, Harare
University of Zimbabwe
Musoro, Godfrey
Zimbabwe, Harare
University of Zimbabwe
Taziwa, Fabian
Zimbabwe, Harare
University of Zimbabwe
Chimbetete, Cleophas
Zimbabwe, Harare
University of Zimbabwe
Chakonza, L.
Zimbabwe, Harare
University of Zimbabwe
Mawora, A.
Zimbabwe, Harare
University of Zimbabwe
Muvirimi, C.
Zimbabwe, Harare
University of Zimbabwe
Svovanapasis, P.
Zimbabwe, Harare
University of Zimbabwe
Simango, M.
Zimbabwe, Harare
University of Zimbabwe
Chirema, O.
Zimbabwe, Harare
University of Zimbabwe
Machingura, J.
Zimbabwe, Harare
University of Zimbabwe
Mutsai, Shirley
Zimbabwe, Harare
University of Zimbabwe
Phiri, Misheck Nkalo
Zimbabwe, Harare
University of Zimbabwe
Bafana, Themelihle
Zimbabwe, Harare
University of Zimbabwe
Chirara, Michael M.
Zimbabwe, Harare
University of Zimbabwe
Muchabaiwa, Lazarus
Zimbabwe, Harare
University of Zimbabwe
Muzambi, Margaret
Zimbabwe, Harare
University of Zimbabwe
Chigwedere, Edward
Zimbabwe, Harare
University of Zimbabwe
Pascoe, Margaret J.
Zimbabwe, Harare
University of Zimbabwe
Warambwa, Colin
Zimbabwe, Harare
University of Zimbabwe
Mapinge, F.
Zimbabwe, Harare
University of Zimbabwe
Makota, S.
Zimbabwe, Harare
University of Zimbabwe
Jamu, A.
Zimbabwe, Harare
University of Zimbabwe
Ngorima, Nicoletta
Zimbabwe, Harare
University of Zimbabwe
Chirairo, H.
Zimbabwe, Harare
University of Zimbabwe
Chitsungo, S.
Zimbabwe, Harare
University of Zimbabwe
Chimanzi, Joy
Zimbabwe, Harare
University of Zimbabwe
Maweni, C.
Zimbabwe, Harare
University of Zimbabwe
Warara, R.
Zimbabwe, Harare
University of Zimbabwe
Matongo, M.
Zimbabwe, Harare
University of Zimbabwe
Mudzingwa, Shepherd
Zimbabwe, Harare
University of Zimbabwe
Jangano, Maureen
Zimbabwe, Harare
University of Zimbabwe
Moyo, Kundai
Zimbabwe, Harare
University of Zimbabwe
Vere, L.
Zimbabwe, Harare
University of Zimbabwe
Machingura, Ian
Zimbabwe, Harare
University of Zimbabwe
Ronald, Allan R.
Uganda, Kampala
Makerere University
Kambungu, A.
Uganda, Kampala
Makerere University
Lutwama, Fred
Uganda, Kampala
Makerere University
Mambule, Ivan Kiggundu
Uganda, Kampala
Makerere University
Nabankema, Evelyn
Uganda, Kampala
Makerere University
Nalumenya, Ruth
Uganda, Kampala
Makerere University
Namuli, Teopista
Uganda, Kampala
Makerere University
Namata, Ibrahim
Uganda, Kampala
Makerere University
Lubwama, E.
Uganda, Kampala
Makerere University
Buluma, E.
Uganda, Kampala
Makerere University
Ojiambo, Henry
Uganda, Kampala
Makerere University
Wanyama, Jane Namukasa
Uganda, Kampala
Makerere University
Nabongo, Patrick
Uganda, Kampala
Makerere University
Oyugi, Jessica H.
Uganda, Kampala
Makerere University
Muganzi, Alex M.
Uganda, Kampala
Makerere University
Twijukye, C.
Uganda, Kampala
Makerere University
Byakwaga, Helen
Uganda, Kampala
Makerere University
Ochai, Robert
Uganda, Entebbe
The Aids Support Organisation Taso
Coutinho, Alex G.
Uganda, Entebbe
The Aids Support Organisation Taso
Etukoit, Bernard Michael
Uganda, Entebbe
The Aids Support Organisation Taso
Boocock, K.
United Kingdom, London
Imperial College London
Puddephatt, C.
United Kingdom, London
Imperial College London
Grundy, Caroline
United Kingdom, London
Imperial College London
Winogron, D.
United Kingdom, London
Imperial College London
Darbyshire, J. H.
United Kingdom, London
Mrc Clinical Trials Unit
Burke, Andrew
United Kingdom, London
Mrc Clinical Trials Unit
Bray, Dorothy H.
United Kingdom, London
Mrc Clinical Trials Unit
Babiker, Abdel G.A.G.
United Kingdom, London
Mrc Clinical Trials Unit
Wilkes, Helen C.
United Kingdom, London
Mrc Clinical Trials Unit
Rauchenberger, Mary
United Kingdom, London
Mrc Clinical Trials Unit
Sheehan, Stephen
United Kingdom, London
Mrc Clinical Trials Unit
Taylor, Kay
United Kingdom, London
Mrc Clinical Trials Unit
Spyer, Moira J.
United Kingdom, London
Mrc Clinical Trials Unit
Ferrier, Alexander
United Kingdom, London
Mrc Clinical Trials Unit
Naidoo, Bethany
United Kingdom, London
Mrc Clinical Trials Unit
Dunn, David T.
United Kingdom, London
Mrc Clinical Trials Unit
Goodall, Ruth L.
United Kingdom, London
Mrc Clinical Trials Unit
Kaleebu, Pontiano P.
Unknown Affiliation
Morris, Lynn G.
Unknown Affiliation
Dunn, David D.
Unknown Affiliation
Goodall, Ruth L.
Unknown Affiliation
Kapaata, Anne A.
Unknown Affiliation
Katuramur, M.
Unknown Affiliation
Magala, Rose
Unknown Affiliation
Magambo, Brian
Unknown Affiliation
Mataruka, K.
Unknown Affiliation
McCormick, Adele L.
Unknown Affiliation
Mugarura, Lincoln
Unknown Affiliation
Musunga, T.
Unknown Affiliation
Nabankkema, M.
Unknown Affiliation
Nkalubo, J.
Unknown Affiliation
Nkurunziza, Peter M.
Unknown Affiliation
Parry, Chris M.
Unknown Affiliation
Robertson, V.
Unknown Affiliation
Spyer, Moira J.
Unknown Affiliation
Yirrell, D.
Unknown Affiliation
Weller, Ian V.D.
Unknown Affiliation
Babiker, A. G.
Unknown Affiliation
Bahendeka, Silver Karaireho
Unknown Affiliation
Bassett, M.
Unknown Affiliation
Chogo Wapakhabulo, A.
Unknown Affiliation
Darbyshire, Janet H.
Unknown Affiliation
Gazzard, Brian George L.
Unknown Affiliation
Grosskurth, Heiner
Unknown Affiliation
Mugurungi, Owen M.
Unknown Affiliation
Mugyenyi, P.
Unknown Affiliation
Loeliger, Edde
Unknown Affiliation
Naidoo, Poobalan
Unknown Affiliation
Rahim, Sibtain
Unknown Affiliation
Rooney, James F.
Unknown Affiliation
Smith, Marshagne
Unknown Affiliation
Snowden, Wendy B.
Unknown Affiliation
Steens, Jean Marc
Unknown Affiliation
Breckenridge, Alasdair M.
Unknown Affiliation
McLaren, A.
Unknown Affiliation
Hill, Catherine Mary
Unknown Affiliation
Matenga, Jonathan Arthur
Unknown Affiliation
Pozniak, Anton Louis
Unknown Affiliation
Serwadda, David Musoke
Unknown Affiliation
Peto, Tunde
Unknown Affiliation
Palfreeman, Adrian J.
Unknown Affiliation
Borok, Margaret Ziona
Unknown Affiliation
Statistics
Citations: 13
Authors: 220
Affiliations: 11
Identifiers
Doi:
10.1186/1742-6405-11-32
ISSN:
17426405
Research Areas
Infectious Diseases
Noncommunicable Diseases