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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Procalcitonin and C-reactive protein as predictors of blood culture positivity among hospitalised children with severe pneumonia in Mozambique
Tropical Medicine and International Health, Volume 17, No. 9, Year 2012
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Description
Objectives To evaluate the benefits of using procalcitonin (PCT) and C-reactive protein (CRP) as pre-screening tools to predict blood culture positivity among Mozambican children with clinical severe pneumonia (CSP). Methods 586 children <5years with CSP and no concurrent malaria fulfilled criteria to be included in the study groups. We determined PCT and CRP for all children with positive bacterial culture (BC+ group, n=84) and of a random selection of children with negative bacterial culture (BC- group, n=246). Results PCT and CRP levels were higher in the BC+ group than the BC- one (PCT: median 7.73 versus 0.48ng/ml, P<0.001; CRP: 177.65mg/l vs. 26.5mg/l, P<0.001). In multivariate analysis, PCT was the only independent predictor of the group. To be used as pre-screening tool, PCT presented higher specificities for predetermined sensitivities (≥85%) than CRP. Pursuing a sensitivity of 95%, PCT could reduce the need for bacterial culture by 49% and overall diagnosis costs by 7-35% [assuming variable costs for PCT measurement (ranging from 10 to 30USD) and a fixed cost of 72.5USD per blood culture]. Conclusions Among hospitalised children with CSP and absence of concurrent malaria, PCT pre-screening could help reduce the number of blood cultures and diagnosis costs by specifically targeting patients more likely to yield positive results. © 2012 Blackwell Publishing Ltd.
Authors & Co-Authors
Díez-Padrisa, Núria
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Bassat, Quique
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Morais, Luís
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
O'Callaghan-Gordo, Cristina
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
MacHevo, Sónia
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Universidade Eduardo Mondlane
Nhampossa, Tacilta
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Ibarz-Pavón, Ana Belén
Spain, Barcelona
Instituto de Salud Global de Barcelona
Quintò, Llorenç L.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Roca, Anna
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Statistics
Citations: 35
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2012.03035.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Mozambique