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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment
AIDS, Volume 17, No. 8, Year 2003
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Description
Objective: To examine baseline predictors of T-cell receptor rearrangement excision circle (TREC) levels and their changes during treatment with combined antiretroviral therapy. Methods: Peripheral blood and lymph node lymphocytes were examined for the presence of TREC by real-time polymerase chain reaction and circulating lymphocyte phenotypes were examined by flow cytometry. Correlates for CD4 and CD8 cell TREC levels at baseline were identified among CD4 and CD8 immunophenotypes, viral load and patient demographics; the significance of TREC changes after initiation of antiretroviral therapy was assessed. Results: Circulating TREC levels correlated inversely with age, with HIV RNA levels, with activation markers on circulating T cells and with naive CD4 but not CD8 cell frequencies. With initiation of antiretroviral therapy, TREC and naive T cell frequencies increased in peripheral blood during the first 2 weeks of treatment and these changes correlated negatively with TREC frequencies in lymph node aspirates, particularly among CD8 T cells. Conclusions: These findings suggest that recent thymic emigrants are sequestered in lymphoid tissue during uncontrolled HIV replication and are selectively released into circulation rapidly after initiation of antiretroviral therapies. © 2003 Lippincott Williams & Wilkins.
Authors & Co-Authors
Diaz, Mireya
United States, Cleveland
University Hospitals Case Medical Center
Douek, Daniel Cesar
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Valdez, Hernan
United States, Cleveland
University Hospitals Case Medical Center
Hill, Brenna J.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Peterson, Dolores
United States, Dallas
Ut Southwestern Medical Center
Sanne, Ian
South Africa, Johannesburg
University of the Witwatersrand
Piliero, Peter J.
United States, Albany
Albany Medical College
Koup, Richard A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Green, Sylvan B.
United States, Tucson
University of Arizona Cancer Center
Schnittman, Steven M.
United States, New York
Bristol-myers Squibb
Lederman, Michael M.
United States, Cleveland
University Hospitals Case Medical Center
Statistics
Citations: 47
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1097/00002030-200305230-00005
Research Areas
Health System And Policy
Infectious Diseases