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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Risk factors for severe malaria in Bamako, Mali: A matched case-control study
Microbes and Infection, Volume 6, No. 6, Year 2004
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Description
The aim of this case-control study was to identify epidemiological risk factors for severe malaria among children living in Bamako, a malaria-endemic area. For this, 260 healthy community controls were matched to 130 patients with severe malaria. Conditional multiple logistic regression analysis indicated that all examined independent factors associated with severe malaria are directly related to characteristics of the child's mother, with the exception of the child's own yellow fever vaccination history (odds ratio (OR): 1.93, 95% confidence intervals (CI95%) [1.10-3.37]). The following characteristics were all associated with a decreased risk of severe malaria in the child: maternal education (OR: 0.52, CI95% [0.31-0.86]), the mother's adequate knowledge about malaria (OR: 0.46, 95% CI95% [0.25-0.86]), her use of mosquito bed nets (OR: 0.53, CI95% [0.30-0.92]) and breast-feeding for at least 2 years (OR: 0.57, CI95% [0.33-0.94]). Conversely, chronic maternal disease (OR: ̇3.16, CI 95% [1.31-7.61]) was associated with an increased risk of severe malaria. These findings strongly support the hypothesis that maternal factors are central to the development of severe malaria in children. Programmes aiming to improve both maternal health and maternal education may reduce the incidence of severe malaria in children and should therefore be advocated in Bamako and in areas with similar epidemiological patterns for malaria. © 2004 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Safeukui-Noubissi, Innocent
France, Marseille
Aix Marseille Université
Ranque, S.
France, Marseille
Aix Marseille Université
Poudiougou, Belco
Mali, Bamako
University of Bamako
Keita, Modibo T.
Mali, Bamako
University of Bamako
Traoré, Abdoulaye Mamadou
Mali, Bamako
University of Bamako
Traoré, Diamori
Mali, Bamako
University of Bamako
Diakité, Mahamadou L.
Mali, Bamako
University of Bamako
Cissé, Mahamadou Balla
Mali, Bamako
Gabriel Toure Hospital
Kéita, Mamadou Marouf
Mali, Bamako
Gabriel Toure Hospital
Dessein, Alain Jacques J.
France, Marseille
Aix Marseille Université
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Statistics
Citations: 45
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.micinf.2004.02.007
ISSN:
12864579
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Mali