Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study
PLoS ONE, Volume 8, No. 6, Article e66135, Year 2013
Notification
URL copied to clipboard!
Description
Background: HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). Methods: We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region. Results: Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm3, IQR (83-247) among HIV-2 infected patients and 146 cells/mm3, IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm3 after 24 months on ART for HIV-2 patients and 169 cells/mm3 for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3). Conclusions: This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population. © 2013 Ekouevi et al.
Authors & Co-Authors
Ékouévi, Didier Koumavi
France, Paris
Inserm
Cote D'ivoire, Abidjan
Programme Pac-ci
Togo, Lome
University of Lome
Balestre, Eric
France, Paris
Inserm
Coffie, Patrick A.
Cote D'ivoire, Abidjan
Programme Pac-ci
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Minta, Daouada K.
Mali, Bamako
Hopital National du Point g
Nigeria
Ch Point g
Messou, Eugéne
Cote D'ivoire, Abidjan
Programme Pac-ci
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Cepref-enfants
Burkina Faso
Aconda-cepref
Sawadogo, Adrien
Burkina Faso
Chu Souro Sanou
Minga, Albert Kla
Cote D'ivoire, Abidjan
Centre Médical de Suivi de Donneurs de Sang Cmsds
Cote D'ivoire, Abidjan
Cmsds/cnts
Sow, Papa Salif
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Senegal
Chu Fann
Bissagnéné, Emmanuel
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Gottlieb., Geoffrey S.
United States, Seattle
University of Washington
Dabis, Franćois Ç.Ois
France, Paris
Inserm
Zannou, Djimon Marcel
Burkina Faso
Cnhu Hubert Maga
Ahouada, Carin
Burkina Faso
Cnhu Hubert Maga
Akakpo, Jocelyn
Burkina Faso
Cnhu Hubert Maga
Ahomadégbé, Christelle
Burkina Faso
Cnhu Hubert Maga
Bashi, Jules B.
Burkina Faso
Cnhu Hubert Maga
Gougounon-Houêto, Alice
Burkina Faso
Cnhu Hubert Maga
Azon-Kouanou, Angèle
Burkina Faso
Cnhu Hubert Maga
Houngbè, Fabien
Burkina Faso
Cnhu Hubert Maga
Koumakpaï, Sikiratou A.
Burkina Faso
Cnhu Hubert Maga
Alihonou, Florence
Burkina Faso
Cnhu Hubert Maga
D'Almeida, Marcelline
Burkina Faso
Cnhu Hubert Maga
Hodonou, Irvine
Burkina Faso
Cnhu Hubert Maga
Hounhoui, Ghislaine
Burkina Faso
Cnhu Hubert Maga
Sagbo, Gracien
Burkina Faso
Cnhu Hubert Maga
Tossa-Bagnan, Leïla
Burkina Faso
Cnhu Hubert Maga
Adjide, Herman
Burkina Faso
Cnhu Hubert Maga
Drabo, Joseph Youssouf
Burkina Faso, Ouagadougou
Chu Yalgado
Bognounou, René
Burkina Faso, Ouagadougou
Chu Yalgado
Diendéré, Arnaud Eric
Burkina Faso, Ouagadougou
Chu Yalgado
Traore, Eliezer
Burkina Faso, Ouagadougou
Chu Yalgado
Zoungrana, Lassané A.
Burkina Faso, Ouagadougou
Chu Yalgado
Zerbo, Béatrice
Burkina Faso, Ouagadougou
Chu Yalgado
Sawadogo, Adrien Bruno
Burkina Faso
Chu Souro Sanou
Zoungrana, Jacques
Burkina Faso
Chu Souro Sanou
Héma, Arsène
Burkina Faso
Chu Souro Sanou
Soré, Ibrahim
Burkina Faso
Chu Souro Sanou
Bado, Guillaume
Burkina Faso
Chu Souro Sanou
Tapsoba, Achille
Burkina Faso
Chu Souro Sanou
Yé, Diarra
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Kouéta, Fla
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo, Sylvie Armelle P.
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo-Traoré, Rasmata
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Hiembo, William
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Gansonré, Mady
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Gnokoro, Joachim Charles
Burkina Faso
Aconda-cepref
Koné, Mamadou
Burkina Faso
Aconda-cepref
Kouakou, Guillaume Martial
Burkina Faso
Aconda-cepref
Bosse, Clarisse Amani
Burkina Faso
Aconda-mtct-plus
Brou, Kouakou J.
Burkina Faso
Aconda-mtct-plus
Assi, Achi Isidore
Burkina Faso
Aconda-mtct-plus
Chenal, Henri
Cote D'ivoire, Abidjan
Cirba
Hawerlander, Denise
Cote D'ivoire, Abidjan
Cirba
Soppi, Franck
Cote D'ivoire, Abidjan
Cirba
Abo, Yao
Cote D'ivoire, Abidjan
Cmsds/cnts
Bomisso, Germain I.
Cote D'ivoire, Abidjan
Cmsds/cnts
Amego, Mensah Deborah Noelly
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Andavi, Viviane
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Diallo, Zélica
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ello, Frêdéric Nogbou
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tanon, Aristophane Koffi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Koulé, Serge Olivier
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Anzan, Koffi Charles
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Guéhi, Calixte
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Aka, Edmond Addi
Burkina Faso
Aconda-cepref
Issouf, Koffi Ladji
Burkina Faso
Aconda-cepref
Kouakou, Jean Claude
Burkina Faso
Aconda-cepref
N'Gbeche, Marie Sylvie
Burkina Faso
Aconda-cepref
Touré, Pety
Burkina Faso
Aconda-mtct-plus
Avit-Edi, Divine
Burkina Faso
Aconda-mtct-plus
Kouakou, Kouadio P.
Cote D'ivoire, Abidjan
Cirba
Moh, Magloire
Cote D'ivoire, Abidjan
Cirba
Yao, Valérie Andoblé
Cote D'ivoire, Abidjan
Cirba
Folquet, Madeleine Amorissani
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Dainguy, Marie Evelyne
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kouakou, Cyrille
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Méa-Assandé, Véronique Tanoh
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Oka-Bérété, Gladys
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Zobo, Nathalie
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Acquah, Patrick
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kokora, Marie Berthe
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Eboua, Tanoh François
Cote D'ivoire
Chu Yopougon
Timité-Konan, Marguerite
Cote D'ivoire
Chu Yopougon
Ahoussou, Lucrèce Diecket
Cote D'ivoire
Chu Yopougon
Assouan, Julie Kebé
Cote D'ivoire
Chu Yopougon
Sami, Mabéa Flora
Cote D'ivoire
Chu Yopougon
Kouadio, Clémence
Cote D'ivoire
Chu Yopougon
A Renner, Lorna
Ghana
Korle bu th
Goka, Bamenla Quarm
Ghana
Korle bu th
Welbeck, Jennifer E.
Ghana
Korle bu th
Sackey, Adziri Harold
Ghana
Korle bu th
Owiafe, Seth Ntiri
Ghana
Korle bu th
Wejse, Christian
Guinea-bissau, Bissau
Bandim Health Project
da Silva, Zacarias José
Guinea-bissau, Bissau
Bandim Health Project
Paulo, Joao
Guinea-bissau, Bissau
Bandim Health Project
Rodrigues, Amabélia
Guinea-bissau, Bissau
Bandim Health Project
da Silva, David
Guinea-bissau, Bissau
National Hiv Program Bissau
Medina, Candida
Guinea-bissau
Hospital National Simao Mendes
Oliviera-Souto, Ines
Guinea-bissau, Bissau
Bandim Health Project
Østergaard, Lars Jørgen
Denmark, Aarhus
Aarhus Universitetshospital
Laursen, Alex Lund
Denmark, Aarhus
Aarhus Universitetshospital
Sodemann, Morten
Denmark, Odense
Odense Universitetshospital
Aaby, Peter
Guinea-bissau, Bissau
Bandim Health Project
Fomsgaard, Anders
Denmark, Copenhagen
Statens Serum Institut
Erikstrup, Christian
Unknown Affiliation
Eugen-Olsen, Jesper
Denmark, Hvidovre
Hvidovre Hospital
Maïga, Moussa Youssouffa
Nigeria
Ch Gabriel Toure
Kallé, Abdoulaye
Nigeria
Ch Gabriel Toure
Katilé, Drissa
Nigeria
Ch Gabriel Toure
Traoré, Hammar Alassane
Nigeria
Ch Point g
Cissé, Tidiani
Nigeria
Ch Point g
Dembélé, Mamadou Y.
Nigeria
Ch Point g
Fomba, Mahamadou
Nigeria
Ch Point g
Kaya, Assêtou Soukho
Nigeria
Ch Point g
Traoré, Abdoulaye Mamadou
Nigeria
Ch Point g
Traoré, Hamady H.
Nigeria
Ch Point g
Touré, Amadou Abathina
Nigeria
Ch Point g
Dicko-Traoré, Fatoumata B.
Nigeria, Benin
Ubth
Sylla, Mariam Moustapha
Nigeria, Benin
Ubth
Koné, Niaboula
Nigeria, Benin
Ubth
N'Diaye, Clémentine
Nigeria, Benin
Ubth
Traoré, Mamadou M.
Nigeria, Benin
Ubth
Charurat, Man
Unknown Affiliation
Ajayi, Samuel Oluwole
Nigeria, Abuja
Uath
Dapiap, Stephen B.
Nigeria, Abuja
Uath
Igbinoba, Festus
Nigeria, Abuja
National Hospital, Abuja
Benson, Okwara
Nigeria, Benin
Ubth
Adebamowo, Clement
Nigeria, Benin
Ubth
Diop, Bernard Marcel
Senegal
Chu Fann
Manga, Noël Magloire
Senegal
Chu Fann
Tine, Judicaël Malick
Senegal
Chu Fann
Sy, Haby Signaté
Unknown Affiliation
Ba, Abou
Unknown Affiliation
Dior, Hélène
Unknown Affiliation
Faye, Malick L.
Unknown Affiliation
Gueye, Ramatoulaye Diagne
Unknown Affiliation
Mbaye, Aminata Diack
Unknown Affiliation
Patassi, Akouda Akessiwe
Togo
Chu Tokoin
Kotosso, Awerou
Togo
Chu Tokoin
Gbadamassi, Gafarou
Togo
Chu Tokoin
Lawson-Evi, Annette Koko
Togo
Chu Tokoin
Atakouma, Yawo Dzayissè
Togo
Chu Tokoin
Takassi, Elom Ounoo
Togo
Chu Tokoin
Dabis, François
France, Paris
Inserm
Cote D'ivoire, Abidjan
Programme Pac-ci
Arrivé, Élise
France, Paris
Inserm
Coffié, Patrick Ahuatchi
Unknown Affiliation
Ekouévi, Didier Koumavi
Unknown Affiliation
Jaquet, Antoine
France, Paris
Inserm
Leroy, Valeriane
France, Paris
Inserm
Lewden, Charlotte
France, Paris
Inserm
Sasco, Annie Jeanne
France, Paris
Inserm
Azani, Jean Claude
Unknown Affiliation
Allou, Gérard
Unknown Affiliation
Bohossou, Franck
Unknown Affiliation
Karcher, Sophie
France, Paris
Inserm
Gonsan, Jules Mahan
Unknown Affiliation
Le Carrou, Jérôme
France, Paris
Inserm
Lenaud, Sêverin
Unknown Affiliation
Nchot, Célestin
Unknown Affiliation
Malateste, Karen
France, Paris
Inserm
Siloué, Bertine
Unknown Affiliation
Doring, Alexandra
France, Paris
Inserm
Kouakou, Adrienne V.
Unknown Affiliation
Rabourdin, Elodie
France, Paris
Inserm
Anglaret, Xavier
France, Paris
Inserm
Ba, Boubacar
Unknown Affiliation
Essanin, Jean Bosco
Unknown Affiliation
Ciaranello, Andrea L.
Unknown Affiliation
Datté, Sébastien Atta
Unknown Affiliation
Desmonde, Sophie
France, Paris
Inserm
Diby, Jean Serge Elvis
Unknown Affiliation
Horo, Apollinaire Gninlgninrin
Unknown Affiliation
Malvy, Denis Jean Marie
France, Paris
Inserm
Meless, David Guanga
Unknown Affiliation
Mounkaila-Harouna, Aïda
France, Paris
Inserm
Ndondoki, Camille
France, Paris
Inserm
Shiboski, Caroline H.
Unknown Affiliation
Thíébaut, Rodolphe
France, Paris
Inserm
Statistics
Citations: 39
Authors: 179
Affiliations: 36
Identifiers
Doi:
10.1371/journal.pone.0066135
ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Multi-countries
Benin
Ivory Coast
Mali
Senegal
Participants Gender
Female