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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Vasculogenesis drives pulmonary vascular growth in the developing chick embryo
Developmental Dynamics, Volume 233, No. 1, Year 2005
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Description
Formation of the pulmonary vasculature has been described as occurring by outgrowth of existing vessels (angiogenesis), de novo formation of new vessels (vasculogenesis), or a combination of both processes. Uncertainty about the contribution of angiogenesis and vasculogenesis to pulmonary vascular formation is partly due to methodologic approaches. Evidence in favor of angiogenesis stems from studies that used vascular-filling methods. Such methods identify only directly continuous lumina. Evidence for vasculogenesis has been provided by the use of molecular markers of blood vessel endothelium. Use of both methods has not been combined in the same species, however. We hypothesized, based on published evidence from quail and mouse, that chick pulmonary vascular formation occurs by vasculogenesis. To test that hypothesis, we used vascular filling, serial section, and immunohistochemical methods to analyze the developing lungs of chick embryos from Hamburger and Hamilton stages 20 to 43. Vascular filling suggested that the lumen of the pulmonary arteries sprouted from the sixth pharyngeal arch arteries. However, serial sections and immunohistochemical localization of fetal liver kinase-1 protein, the receptor for vascular endothelial growth factor, showed that the pulmonary arterial tree formed from endothelial cell precursors and coalescence of isolated blood vessels in the mediastinal splanchnic mesenchyme centrally to the developing lung tissue distally. Pulmonary veins grew from the left atrium to the developing lungs. Pulmonary blood vessel formation occurred continuously throughout the embryonic period studied. Our results show that vasculogenesis is the main process by which the pulmonary vasculature forms in the developing chick embryo. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Anderson-Berry, Ann
United States, Salt Lake City
The University of Utah
O'Brien, Elizabeth A.
United States, Salt Lake City
The University of Utah
Bleyl, Steven B.
United States, Salt Lake City
The University of Utah
Lawson, Aaron N.L.
United States, Salt Lake City
The University of Utah
Ghana, Accra
University of Ghana
Gundersen, Nancy
United States, Salt Lake City
The University of Utah
Ryssman, Daniel
United States, Salt Lake City
The University of Utah
Sweeley, John
United States, Salt Lake City
The University of Utah
Dahl, Mar Janna
United States, Salt Lake City
The University of Utah
Drake, Christopher J.
United States, Charleston
Medical University of South Carolina
Schoenwolf, Gary C.
United States, Salt Lake City
The University of Utah
Albertine, Kurt H.
United States, Salt Lake City
The University of Utah
Statistics
Citations: 36
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1002/dvdy.20296
ISSN:
10588388
Research Areas
Cancer