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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
Nature Communications, Volume 10, No. 1, Article 1092, Year 2019
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Description
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease. © 2019, The Author(s).
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Authors & Co-Authors
Lee, Amy H.Y.
Canada, Vancouver
The University of British Columbia
Shannon, Casey P.
Unknown Affiliation
Amenyogbe, Nelly A.
Canada, Vancouver
The University of British Columbia
Australia, Perth
Telethon Kids Institute
Bennike, Tue Bjerg
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Denmark, Aalborg
Aalborg University
Diray-Arce, Joann
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Idoko, Olubukola T.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Germany, Munich
Ludwig-maximilians-universität München
Ben-Othman, Rym
Canada, Vancouver
Bc Children's Hospital
Pomat, William S.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Van Haren, Simon Daniël
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Lê Cao, Kim Anh
Australia, Melbourne
University of Melbourne
Cox, Momodou
Gambia, Banjul
Medical Research Council Laboratories Gambia
Darboe, Alansana
Gambia, Banjul
Medical Research Council Laboratories Gambia
Falsafi, Reza F.
Canada, Vancouver
The University of British Columbia
Harbeson, Danny J.
Canada, Vancouver
The University of British Columbia
He, Daniel
Unknown Affiliation
Hinshaw, Samuel J.H.
Canada, Vancouver
The University of British Columbia
Canada, Vancouver
British Columbia Cancer Agency
Ndure, Jorjoh
Gambia, Banjul
Medical Research Council Laboratories Gambia
Njie-Jobe, Jainaba
Gambia, Banjul
Medical Research Council Laboratories Gambia
Pettengill, Matthew Aaron
United States, Boston
Boston Children's Hospital
United States, Philadelphia
Thomas Jefferson University
Richmond, Peter
Australia, Perth
Uwa Medical School
Australia, Perth
The University of Western Australia
Ford, Rebecca L.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Saleu, Gerard
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Masiria, Geraldine
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Matlam, John Paul
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Kirarock, Wendy S.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Roberts, Elishia
Gambia, Banjul
Medical Research Council Laboratories Gambia
Malek, Mehrnoush
Canada, Vancouver
British Columbia Cancer Agency
Sánchez-Schmitz, Guzmán
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Singh, Amrit
Canada, Vancouver
The University of British Columbia
Angelidou, Asimenia
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Smolen, K. K.
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Vo, Diana
United States, Boston
Boston Children's Hospital
Kraft, Ken
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
McEnaney, Kerry
United States, Boston
Boston Children's Hospital
Canada, Vancouver
The University of British Columbia
Vignolo, Sofia M.
United States, Boston
Boston Children's Hospital
Marchant, Arnaud
Belgium, Brussels
Université Libre de Bruxelles
Brinkman, Ryan R.
Canada, Vancouver
British Columbia Cancer Agency
Canada, Vancouver
The University of British Columbia
Ozonoff, Al
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Hancock, Robert E.W.
Canada, Vancouver
The University of British Columbia
van den Biggelaar, Anita Huiberdina Johanna
Australia, Perth
The University of Western Australia
Steen, Hanno
United States, Boston
Boston Children's Hospital
Gambia, Banjul
Medical Research Council Laboratories Gambia
Tebbutt, Scott J.
Canada, Vancouver
Centre for Heart Lung Innovation
Canada, Vancouver
The University of British Columbia
Kampmann, Beate B.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, London
London School of Hygiene & Tropical Medicine
Levy, Ofer
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Kollmann, Tobias R.
Canada, Vancouver
The University of British Columbia
Canada, Vancouver
Bc Children's Hospital
Australia, Perth
Telethon Kids Institute
Statistics
Citations: 109
Authors: 45
Affiliations: 18
Identifiers
Doi:
10.1038/s41467-019-08794-x
ISSN:
20411723
Study Design
Cohort Study
Study Locations
Multi-countries