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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Correlates of adherence to antiretroviral therapy in HIV-infected children in Lomé, Togo, West Africa
AIDS and Behavior, Volume 13, No. 1, Year 2009
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Description
We assessed pediatric adherence to antiretroviral therapy (ART) and examined associated factors among children in Togo, West Africa. Structured interviews of caregivers of consecutively enrolled HIV-infected children receiving ART in three HIV/AIDS care centers in Lome, Togo were conducted. Child perfect adherence reflected caregivers' report of no antiretroviral drug doses missed neither in the past 4 days nor in the month before the interview. A total of 74 ART-treated children were included (median age 6 years). Of these, 42% of caregivers declared perfect adherence. In univariate analyses, the major factors relating to child non-adherence were: being female, living in an individual setting (vs. compound with enlarged family), receiving other ART than an NNRT-based regimen, drug regimens with six pills/spoons or more per day, caregiver other than biological parent, caregiver not declaring HIV-status, not participating to support groups and having perceived difficulty of antiretroviral (ARV) administration. In multivariate analysis, female gender, living in an individual setting, receiving other than NNRTI-based regimen and caregivers' perceived difficulty of ARV administration remained independently associated with the reported child's non-adherence. These data show low rates of perfect adherence to ART in children in West Africa, influenced by child and caregiver characteristics and suggest a need for counseling and education interventions as well as continuous psychological and social support. © 2008 Springer Science+Business Media, LLC.
Authors & Co-Authors
Polisset, Julie
France, Bordeaux
Université de Bordeaux
Ametonou, Francine
France, Bordeaux
Université de Bordeaux
Arrivé, Élise
France, Bordeaux
Université de Bordeaux
Aho, Anthony
Togo, Lome
Research Associate
Pérez, Freddy
France, Bordeaux
Université de Bordeaux
Statistics
Citations: 71
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1007/s10461-008-9437-6
ISSN:
10907165
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Multi-countries
Togo
Participants Gender
Female