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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence
American Journal of Tropical Medicine and Hygiene, Volume 74, No. 4, Year 2006
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Description
Two potential malaria virulence factors, parasite multiplication rate (PMR) and red blood cell selectivity (measured as selectivity index [SI]), were assessed in Plasmodium falciparum clinical isolates from Mali and Kenya. At both sites, PMRs were low (Kenya median = 2.2, n = 33; Mali median = 2.6, n = 61) and did not differ significantly between uncomplicated and severe malaria cases. Malian isolates from hyperparasitemic patients had significantly lower PMRs (median = 1.8, n = 19) than other Malian isolates (uncomplicated malaria median = 3.1, n = 23; severe malaria median = 2.8, n = 19; P = 0.03, by Kruskal-Wallis test). Selective invasion occurred at both sites (Kenya geometric mean SI = 1.9, n = 98; Mali geometric mean SI = 1.6, n = 104), and there was no significant association between the SI and malaria severity. Therefore, in contrast to previous results from Thailand, we found no association of PMR and SI with malaria severity in African children. This raises the possibility of differences in the mechanisms of malaria virulence between sub-Saharan Africa and Asia. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Deans, Anne Marie
United Kingdom, Edinburgh
The University of Edinburgh
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Thera, Mahamadou Ali
Mali, Bamako
Faculté de Médecine de Pharmacie et D'odonto-stomatologie
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Koné, Abdoulaye Kassoum
Mali, Bamako
Faculté de Médecine de Pharmacie et D'odonto-stomatologie
Doumbo, Ogobara K.
Mali, Bamako
Faculté de Médecine de Pharmacie et D'odonto-stomatologie
Kai, Oscar K.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Marsh, Kevin
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
MacKinnon, Margaret J.
United Kingdom, Cambridge
University of Cambridge
Raza, Ahmed J.
United Kingdom, Edinburgh
The University of Edinburgh
Rowe, Jane Alexandra
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 61
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2006.74.554
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya
Mali