Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Emergence of a globally dominant inchi1 plasmid type associated with multiple drug resistant typhoid
PLoS Neglected Tropical Diseases, Volume 5, No. 7, Article e1245, Year 2011
Notification
URL copied to clipboard!
Description
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. Typhi now dominate drug sensitive equivalents in many regions. MDR in S. Typhi is almost exclusively conferred by self-transmissible IncHI1 plasmids carrying a suite of antimicrobial resistance genes. We identified over 300 single nucleotide polymorphisms (SNPs) within conserved regions of the IncHI1 plasmid, and genotyped both plasmid and chromosomal SNPs in over 450 S. Typhi dating back to 1958. Prior to 1995, a variety of IncHI1 plasmid types were detected in distinct S. Typhi haplotypes. Highly similar plasmids were detected in co-circulating S. Typhi haplotypes, indicative of plasmid transfer. In contrast, from 1995 onwards, 98% of MDR S. Typhi were plasmid sequence type 6 (PST6) and S. Typhi haplotype H58, indicating recent global spread of a dominant MDR clone. To investigate whether PST6 conferred a selective advantage compared to other IncHI1 plasmids, we used a phenotyping array to compare the impact of IncHI1 PST6 and PST1 plasmids in a common S. Typhi host. The PST6 plasmid conferred the ability to grow in high salt medium (4.7% NaCl), which we demonstrate is due to the presence in PST6 of the Tn6062 transposon encoding BetU. © 2011 Holt et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3139670/bin/pntd.0001245.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3139670/bin/pntd.0001245.s002.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3139670/bin/pntd.0001245.s003.xls
Authors & Co-Authors
Holt, Kathryn E.
United Kingdom, Hinxton
Wellcome Sanger Institute
Australia, Melbourne
University of Melbourne
Phan, Minh Duy
United Kingdom, Hinxton
Wellcome Sanger Institute
Australia, Brisbane
The University of Queensland
Baker, Stephen G.
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Duy, Pham Thanh
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Nga, Tran Vu Thieu
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Nair, Satheesh
United Kingdom, London
Public Health England
Turner, Arthur Keith
United Kingdom, Hinxton
Wellcome Sanger Institute
Walsh, Ciara
United States, Dublin
Food Safety Authority of Ireland
Fanning, Séamus
Ireland, Dublin
University College Dublin
Farrell-Ward, Sinéad
Ireland, Dublin
University College Dublin
Dutta, Dr Shanta
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Kariuki, Samuel M.
Kenya, Nairobi
Kenya Medical Research Institute
WeillFranç, François Xavier
France, Paris
Institut Pasteur, Paris
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
Dougan, Gordon J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Wain, John R.
United Kingdom, London
Public Health England
Statistics
Citations: 123
Authors: 16
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pntd.0001245
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Genetics And Genomics
Infectious Diseases