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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Addressing the achilles' heel in the HIV care continuum for the success of a test-and-treat strategy to achieve an AIDS-free generation
Clinical Infectious Diseases, Volume 59, No. SUPPL.1, Year 2014
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Description
Mathematical models and recent data from ecological, observational, and experimental studies show that antiretroviral therapy (ART) is effective for both treatment and prevention of HIV, validating the treatment as prevention (TasP) approach. Data from a variety of settings, including resource-rich and-limited sites, show that patient attrition occurs at each stage of the human immunodeficiency virus (HIV) treatment cascade, starting with the percent unaware of their HIV infection in a population and linkage to care after diagnosis, assessment of ART readiness, receipt of ART, and finally long-term virologic suppression. Therefore, in order to implement TasP, we must first define practical and effective linkage to care, acceptability of treatment, and adherence and retention monitoring strategies, as well as the cost-effectiveness of such strategies. Ending this pandemic will require the combination of political will, resources, and novel effective interventions that are not only feasible and cost effective but also likely to be used in combination across successive steps on the HIV treatment cascade. © 2014 The Author .
Authors & Co-Authors
Nachega, J. B.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Uthman, Olalekan A.
United Kingdom, Coventry
Warwick Medical School
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Del Rio, Carlos D.
United States, Atlanta
Emory University
Mugavero, Michael J.
United States, Birmingham
The University of Alabama at Birmingham
Rees, Helen V.
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Mills, Edward J.
United States, Stanford
Stanford University School of Medicine
Canada, Ottawa
University of Ottawa
Statistics
Citations: 99
Authors: 6
Affiliations: 10
Identifiers
Doi:
10.1093/cid/ciu299
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study