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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Procedures for collection of induced sputum specimens from children
Clinical Infectious Diseases, Volume 54, No. SUPPL. 2, Year 2012
Notification
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Description
In most settings, sputum is not routinely collected for microbiological diagnosis from children with lower respiratory disease. To evaluate whether it is feasible and diagnostically useful to collect sputum in the Pneumonia Etiology Research for Child Health (PERCH) study, we reviewed the literature on induced sputum procedures. Protocols for induced sputum in children were collated from published reports and experts on respiratory disease and reviewed by an external advisory group for recommendation in the PERCH study. The advisory group compared 6 protocols: 4 followed a nebulization technique using hypertonic saline, and 2 followed a chest or abdomen massage technique. Grading systems for specimen quality were evaluated. Collecting sputum from children with lower respiratory tract illness is feasible and is performed around the world. An external advisory group recommended that sputum be collected from children hospitalized with severe and very severe pneumonia who participate in the PERCH study provided no contraindications exist. PERCH selected the nebulization technique using hypertonic saline. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3297553/bin/supp_54_suppl-2_S140__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3297553/bin/supp_cir1069_8_Grant_Supplementary_Tables.doc
Authors & Co-Authors
Grant, Lindsay R.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Hammitt, Laura L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Murdoch, David Roger
New Zealand, Dunedin
University of Otago
New Zealand, Christchurch
Canterbury Health Laboratories
O'Brien, Katherine L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Scott, John Anthony Gerard
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 57
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1093/cid/cir1069
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Maternal And Child Health