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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Parameters governing invasive disease propensity of non-M1 serotype group A Streptococci
Journal of Innate Immunity, Volume 2, No. 6, Year 2010
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Description
Group A Streptococcus (GAS) causes rare but life-threatening syndromes of necrotizing fasciitis and toxic shock-like syndrome in humans. The GAS serotype M1T1 clone has globally disseminated, and mutations in the control of virulence regulatory sensor kinase (covRS) operon correlate with severe invasive disease. Here, a cohort of non-M1 GAS was screened to determine whether mutation in covRS triggers systemic dissemination in divergent M serotypes. A GAS disease model defining parameters governing invasive propensity of differing M types is proposed. The vast majority of GAS infection is benign. Nonetheless, many divergent M types possess limited capacity to cause invasive infection. M1T1 GAS readily switch to a covRS mutant form that is neutrophil resistant and frequently associated with systemic infection. Whilst non-M1 GAS are shown in this study to less frequently accumulate covRS mutations in vivo, such mutants are isolated from invasive infections and exhibit neutrophil resistance and enhanced virulence. The reduced capacity of non-M1 GAS to switch to the hypervirulent covRS mutant form provides an explanation for the comparatively less frequent isolation of non-M1 serotypes from invasive human infections. Copyright © 2010 S. Karger AG, Basel.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3219504/bin/jin0002-0596-s01.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3219504/bin/jin0002-0596-st01.pdf
Authors & Co-Authors
Maamary, Peter G.
Unknown Affiliation
Sanderson-Smith, Martina L.
Unknown Affiliation
Aziz, Ramy Karam
Unknown Affiliation
Hollands, Andrew
Unknown Affiliation
Colea, Jason N.
Unknown Affiliation
McKay, Fiona C.
Unknown Affiliation
McArthur, Jason D.
Unknown Affiliation
Kirk, Joshua K.
Unknown Affiliation
Cork, Amanda J.
Unknown Affiliation
Keefe, Rachael J.
Unknown Affiliation
Kansal, Rita G.
Unknown Affiliation
Sun, Hongmin
Unknown Affiliation
Taylor, William L.
Unknown Affiliation
Chhatwal, Gursharan S.
Unknown Affiliation
Ginsburg, David
Unknown Affiliation
Nizet, Victor
Unknown Affiliation
Kotb, Malak Y.S.
Unknown Affiliation
Walker, Mark J.
Unknown Affiliation
Statistics
Citations: 44
Authors: 18
Affiliations: 12
Identifiers
Doi:
10.1159/000317640
ISSN:
1662811X
e-ISSN:
16628128
Research Areas
Cancer
Environmental
Study Design
Cohort Study