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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats
BMC Complementary and Alternative Medicine, Volume 14, Article 164, Year 2014
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Description
Background: Pomegranate fruit has been extensively used as a natural medicine in many cultures. The present study was aimed at evaluating the protective effects of pomegranate (Punica granatum) juice against carbon tetrachloride (CCl4)-induced oxidative stress and testes injury in adult Wistar rats.Methods: Twenty eight Wistar albino male rats were divided equally into 4 groups for the assessment of protective potential of pomegranate juice. Rats of group I (control) received only vehicles and had free access to food and water. Rats of groups II and IV were treated with CCl4 (2 ml/kg bwt) via the intraperitoneal route once a week for ten weeks. The pomegranate juice was supplemented via drinking water 2 weeks before and concurrent with CCl4 treatment to group IV. Group III was supplemented with pomegranate juice for twelve weeks. The protective effects of pomegranate on serum sex hormones, oxidative markers, activities of antioxidant enzymes and histopathology of testes were determined in CCl4-induced reproductive toxicity in rats.Results: Pomegranate juice showed significant elevation in testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) those depleted by the injection of CCl4. Activity levels of endogenous testesticular antioxidant enzymes; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) and glutathione (GSH) contents were increased while lipid peroxidation (LPO) and nitric oxide (NO) were decreased with pomegranate juice. Moreover, degeneration of germ and Leydig cells along with deformities in spermatogenesis induced after CCl4 injections were restored with the treatment of pomegranate juice.Conclusion: The results clearly demonstrated that pomegranate juice augments the antioxidant defense mechanism against carbon tetrachloride-induced reproductive toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases. © 2014 Al-Olayan et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4041339/bin/1472-6882-14-164-S1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4041339/bin/1472-6882-14-164-S2.doc
Authors & Co-Authors
Al-Olayan, Ebtesam Mohammed
Saudi Arabia, Riyadh
King Saud University
El-Khadragy, Manal Fawzy
Saudi Arabia, Riyadh
King Saud University
Egypt, Helwan
Faculty of Science
Metwally, Dina Mahmoud Ahmed
Saudi Arabia, Riyadh
King Saud University
Egypt, Zagazig
Faculty of Veterinary Medicine
Abdel Moneim, Ahmed Esmat
Egypt, Helwan
Faculty of Science
Spain, Oviedo
Universidad de Oviedo
Statistics
Citations: 90
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1186/1472-6882-14-164
e-ISSN:
14726882
Research Areas
Environmental
Food Security
Health System And Policy
Sexual And Reproductive Health
Violence And Injury
Participants Gender
Male