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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The Microbial Spectrum of Neonatal Sepsis in Uganda: Recovery of Culturable Bacteria in Mother-Infant Pairs
PLoS ONE, Volume 8, No. 8, Article e72775, Year 2013
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Description
Neonatal sepsis in the developing world is incompletely characterized. We seek to characterize the microbial spectrum involved in sepsis and determine the role of maternal transmission by comparing organisms that can be cultured from septic newborn infants and their mothers. From 80 consecutive mother-infant pairs meeting clinical criteria for neonatal sepsis, we collected infant blood and spinal fluid, and maternal blood and vaginal specimens. Identifiable bacteria were recovered from the blood in 32.5% of infants, and from 2.5% of cerebrospinal fluid cultures, for a total of 35% recoverable putative causative agents. Bacteria recovered from vaginal specimens were not concordant with those recovered from infants. Similarly there was no concordance of bacteria recovered from blood and cerebrospinal fluid. We conclude that relying on traditional bacterial culture techniques does not adequately delineate the role of maternal versus environmental sources of neonatal sepsis in this setting. More sensitive molecular approaches will be needed to properly characterize the maternal and environmental microbial community involved in neonatal sepsis in such developing countries. © 2013 Kiwanuka et al.
Authors & Co-Authors
Kiwanuka, Julius P.
Uganda, Mbarara
Mbarara University of Science and Technology
Bazira, Joel
Uganda, Mbarara
Mbarara University of Science and Technology
Mwanga-Amumpaire, Juliet A.
Uganda, Mbarara
Mbarara University of Science and Technology
Tumusiime, Dickson
Uganda, Mbarara
Mbarara University of Science and Technology
Nyesigire, Eunice
Uganda, Mbarara
Mbarara University of Science and Technology
Lwanga, Nkangi
Uganda, Mbarara
Mbarara University of Science and Technology
Warf, Benjamin Curtis
United States, Boston
Boston Children's Hospital
Kapur, Vivek
United States, University Park
Pennsylvania State University
Poss, Mary L.
United States, University Park
Pennsylvania State University
Schiff, Steven J.
United States, University Park
Pennsylvania State University
Statistics
Citations: 47
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0072775
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Study Locations
Uganda