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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Diagnostic utility of small fiber analysis in skin biopsies from children with chronic pain
Muscle and Nerve, Volume 61, No. 2, Year 2020
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Description
Introduction: Small fiber neuropathies (SFN) are associated with a reduction in quality of life. In adults, epidermal nerve fiber density (END) analysis is recommended for the diagnosis of SFN. In children, END assessment is not often performed. We analyzed small nerve fiber innervation to elucidate the potential diagnostic role of skin biopsies in young patients with pain. Methods: Epidermal nerve fiber density and sudomotor neurite density (SND) were assessed in skin biopsies from 26 patients aged 7 to 20 years (15 female patients) with unexplained chronic pain. The results were compared with clinical data. Results: Epidermal nerve fiber density was abnormal in 50% and borderline in 35% of patients. An underlying medical condition was found in 42% of patients, including metabolic, autoimmune, and genetic disorders. Discussion: Reduction of epidermal nerve fibers can be associated with treatable conditions. Therefore, the analysis of END in children with pain may help to uncover a possible cause and guide potential treatment options. © 2019 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.
Authors & Co-Authors
Kolbel, Heike
Germany, Duisburg
Universität Duisburg-essen
Rutsch, Frank
Germany, Munster
University of Münster
Vanlander, Arnaud Vincent
Belgium, Ghent
Universitair Ziekenhuis Gent
Pogatzki-Zahn, Esther Miriam
Germany, Munster
Universitätsklinikum Münster
Ziegler, Andreas E.
Germany, Heidelberg
Universitätsklinikum Heidelberg
Hahn, Andreas
Germany, Giessen
Justus-liebig-universität Gießen
van Coster, Rudy N.A.
Belgium, Ghent
Universitair Ziekenhuis Gent
Statistics
Citations: 10
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1002/mus.26766
ISSN:
0148639X
Research Areas
Disability
Genetics And Genomics
Maternal And Child Health
Noncommunicable Diseases
Participants Gender
Female