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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Biological and genetic characteristics of HIV infections in Cameroon reveals dual group M and O infections and a correlation between SI-inducing phenotype of the predominant CRF02_AG variant and disease stage
Virology, Volume 310, No. 2, Year 2003
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Description
In Yaounde, Cameroon, HIV-1 group-specific V3 serology on 1469 HIV-positive samples collected between 1996 and 2001 revealed that group O infections remained constant around 1% for 6 years. Only one group N sample was identified and 4.3% reacted with group M and O peptides. Although the sensitivity of the group-specific polymerase chain reaction (PCR) in two genomic regions was not optimal, we confirmed, in at least 6 of 49 (12.2%) dual O/M seropositive samples and in 1 of 9 group O samples, dual infection with group O and M viruses (n = 4) or with group O or M virus and an intergroup recombinant virus (n = 3). Partial env (V3-V5) sequences on a subset of 295 samples showed that at least eight subtypes and five circulating recombinant forms (CRFs) of HIV-1 group M co-circulate; more than 60% were CRF02_AG and 11% had discordant subtype/CRF designations between env and gag. Similarly as for subtype B, the proportion of syncytium-inducing strains increased when CD4 counts were low in CRF02_AG-infected patients. The V3-1oop charge was significantly lower for non-syncytium-inducing strains than for syncytium-inducing strains but cannot be used as an individual marker to predict phenotype. The two predominant HIV-1 variants in Africa, CRF02_AG and subtype C, thus have different biological characteristics. © 2003 Elsevier Science (USA). All rights reserved.
Authors & Co-Authors
Vergne, Laurence
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Bourgeois, Anke
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Mpoudi-Ngolé, Eitel
Cameroon, Yaounde
Military Hospital
Mougnutou, Rose S.
Cameroon, Yaounde
Military Hospital
Mbuagbaw, Josephine Nkwocha
Cameroon, Yaounde
Military Hospital
Liégeois, Florian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Laurent, Christian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Butel, Christelle
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Zekeng, Leópold
Cameroon, Yaounde
Laboratoire de Santé et D'hygiène Mobile
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Statistics
Citations: 103
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/S0042-6822(03)00167-3
ISSN:
00426822
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Cameroon