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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
THE ROLE OF DIETARY AFLATOXIN IN THE GENESIS OF HEPATOCELLULAR CANCER IN DEVELOPING COUNTRIES
The Lancet, Volume 324, No. 8409, Year 1984
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Description
Impaired activity of the liver microsomalmixed-function-oxidase (MFO) system is characteristic of protein malnutrition. It explains the accumulation of aflatoxin (AFB1) in livers of kwashiorkor victims, whose staple foods are usually heavily contaminated with this fungal toxin. Dietary rehabilitation of such children with high-protein foods not only increases the activity of the liver MFO system but also stimulates DNA replication and rapid regeneration of liver cells. Under such circumstances highly reactive metabolites of AFB1, such as the AFB1-epoxide, can produce malignant transformation of the cells by binding covalently with genetic macromolecules. Alternating cycles of food shortage and sufficiency, which usually characterise impoverished communities, and livercell hyperplasia stimulated by the non-genetic cytotoxic effects of AFB1 or parasitic infestation promote rapid replication of the transformed cells. © 1984.
Authors & Co-Authors
Enwonwu, Cyril O.
Nigeria
National Institute for Medical Research
Statistics
Citations: 35
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.1016/S0140-6736(84)91168-1
ISSN:
01406736
Research Areas
Cancer
Disability
Food Security
Genetics And Genomics
Maternal And Child Health