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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Do other cardiovascular risk factors influence the impact of age on the association between blood pressure and mortality? the MORGAM Project
Journal of Hypertension, Volume 32, No. 5, Year 2014
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Description
OBJECTIVE: To investigate age-related shifts in the relative importance of SBP and DBP as predictors of cardiovascular mortality and all-cause mortality and whether these relations are influenced by other cardiovascular risk factors. METHODS: Using 42 cohorts from the MORGAM Project with baseline between 1982 and 1997, 85772 apparently healthy Europeans and Australians aged 19-78 years were included. During 13.3 years of follow-up, 9.2% died (of whom 7.2% died due to stroke and 21.1% due to coronary heart disease, CHD). RESULTS: Mortality risk was analyzed using hazard ratios per 10-mmHg/5-mmHg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, SBP and DBP were analyzed separately for blood pressure (BP) values above and below a cut-point wherein mortality risk was the lowest. For the total population, significantly positive associations were found between stroke mortality and SBP [hazard ratio=1.19 (1.13-1.25)] and DBP at least 78mmHg [hazard ratio=1.08 (1.02-1.14)], CHD mortality and SBP at least 116mmHg [1.20 (1.16-1.24)], and all-cause mortality and SBP at least 120mmHg [1.09 (1.08-1.11)] and DBP at least 82mmHg [1.03 (1.02-1.05)]. BP values below the cut-points were inversely related to mortality risk. Taking into account the age×BP interaction, there was a gradual shift from DBP (19-26 years) to both DBP and SBP (27-62 years) and to SBP (63-78 years) as risk factors for stroke mortality and all-cause mortality, but not CHD mortality. The age at which the importance of SBP exceeded DBP was for stroke mortality influenced by sex, cholesterol, and country risk. CONCLUSION: Age-related shifts to the superiority of SBP exist for stroke mortality and all-cause mortality, and for stroke mortality was this shift influenced by other cardiovascular risk factors. © 2014 Wolters Kluwer Health / Lippincott Williams & Wilkins.
Authors & Co-Authors
Vishram, Julie Kiranjot Kaur
Denmark, Herning
Cardiovascular Research Unit
Denmark, Glostrup
Amtssygehuset I Glostrup
Borglykke, Anders
Denmark, Glostrup
Amtssygehuset I Glostrup
Andreasen, Anne Helms
Denmark, Glostrup
Amtssygehuset I Glostrup
Jeppesen, Jørgen Lykke
Denmark, Herning
Cardiovascular Research Unit
Ibsen, Hans Henning Windeløv
Denmark, Holbak
Holbaek University Hospital
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Broda, Grażyna B.
Poland, Warsaw
Instytut Kardiologii Im. Prymasa Tysiaclecia Stefana Kardynała Wyszynskiego
Palmieri, Luigi
Italy, Rome
Istituto Superiore Di Sanita
Giampaoli, Simona
Italy, Rome
Istituto Superiore Di Sanita
Donfrancesco, Chiara
Italy, Rome
Istituto Superiore Di Sanita
Kee, Frank
United Kingdom, Belfast
Queen's University Belfast
Mancia, Giuseppe
Italy, Milan
Irccs Istituto Auxologico Italiano
Cesana, Giancarlo
Italy, Monza
Azienda Ospedaliera San Gerardo Monza
Kuulasmaa, Kari A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Salomaa, Veikko V.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Sans, Susana
Spain, Barcelona
Institut Catala de la Salut
Ferrières, Jean
France, Toulouse
Hôpital Rangueil
Tamošiunas, Abdonas
Lithuania, Kaunas
Lietuvos Sveikatos Mokslų Universitetas
Söderberg, Stefan
Sweden, Umea
Umeå Universitet
Mcelduff, Patrick
Australia, Callaghan
School of Medicine and Public Health
Arveiler, Dominique
France, Strasbourg
Université de Strasbourg
Paj̧ak, Andrzej
Poland, Krakow
Jagiellonian University Medical College
Olsen, Michael Hecht
Denmark, Odense
Odense Universitetshospital
South Africa, Potchefstroom
North-west University
Statistics
Citations: 23
Authors: 23
Affiliations: 18
Identifiers
Doi:
10.1097/HJH.0000000000000133
ISSN:
02636352
e-ISSN:
14735598
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study