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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Differences in clinical severity of respiratory viral infections in hospitalized children
Scientific Reports, Volume 11, No. 1, Article 5163, Year 2021
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Description
It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient’s disease course is going to be severe. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7933285/bin/41598_2021_84423_MOESM1_ESM.pdf
Authors & Co-Authors
Althouse, Benjamin M.
United States, Bellevue
Institute for Disease Modeling
United States, Seattle
University of Washington
United States, Las Cruces
New Mexico State University
Flasche, Stefan
United Kingdom, London
London School of Hygiene & Tropical Medicine
Toizumi, Michiko
Japan, Nagasaki
Nagasaki University
Nguyen, Hien Anh Thi
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology
Vo, Hien Minh
Viet Nam, Nha Trang
University of Khanh Hoa
Hashizume, Masahiro
Japan, Nagasaki
Nagasaki University
Ariyoshi, Koya
Japan, Nagasaki
Nagasaki University
Anh, Dang Duc
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology
Rodgers, Gail L.
Unknown Affiliation
Klugman, K. P.
Unknown Affiliation
Yoshida, Lay Myint
Japan, Nagasaki
Nagasaki University
Statistics
Citations: 9
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1038/s41598-021-84423-2
ISSN:
20452322
Research Areas
Health System And Policy
Maternal And Child Health