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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
1000 Genomes-based metaanalysis identifies 10 novel loci for kidney function
Scientific Reports, Volume 7, Article 45040, Year 2017
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Description
HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-Analysis of kidney function based on the estimated glomerular filtration rate (EGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until wholegenome sequencing becomes feasible in large samples. © The Author(s) 2017.
Authors & Co-Authors
Gorski, Mathias M.
Germany, Regensburg
Universität Regensburg
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
van der Most, Peter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Teumer, Alexander
Germany, Greifswald
Universitätsmedizin Greifswald
Chu, Audrey Y.
United States, Framingham
Framingham Heart Study
United States, Boston
Harvard Medical School
Li, Man
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
United States, Salt Lake City
The University of Utah
Mijatovic, Vladan
Italy, Verona
Università Degli Studi Di Verona
Nolte, Ilja Maria
Netherlands, Groningen
Rijksuniversiteit Groningen
Cocca, Massimiliano
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Trieste
Università Degli Studi Di Trieste
Taliun, Daniel
Italy, Bolzano
Eurac Research
Gomez, Felicia
United States, St. Louis
Washington University School of Medicine in St. Louis
Li, Yong
Germany, Freiburg Im Breisgau
Universität Freiburg
Tayo, Bamidele O.
United States, Chicago
Loyola University Chicago
Tin, Adrienne
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Aspelund, Thor
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Attia, John Richard
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Bochud, Murielle
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
Borecki, Ingrid B.
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Böttinger, Erwin P.
Unknown Affiliation
Chen, Minghuei
United States, Framingham
Framingham Heart Study
Chouraki, Vincent
France, Lille
Institut Pasteur de Lille
Ciullo, Marina
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Pozzilli
Istituto Neurologico Mediterraneo Neuromed, Pozzilli
Coresh, Josef
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Cornelis, Marylin C.
United States, Chicago
Northwestern University Feinberg School of Medicine
Curhan, Gary C.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Channing Division of Network Medicine
d'Adamo, Adamo P.
Italy, Trieste
Università Degli Studi Di Trieste
Dehghan, Abbas
Netherlands, Rotterdam
Erasmus Mc
Ding, Jingzhong
United States, Winston Salem
Wake Forest University School of Medicine
Eiríksdóttir, Gudný H.
Iceland, Kopavogur
Icelandic Heart Association
Endlich, Karlhans
Germany, Greifswald
Universitätsmedizin Greifswald
Enroth, Stefan
Sweden, Uppsala
Uppsala Universitet
Esko, Tönu
Estonia, Tartu
Tartu Ülikool
Franco, Oscar H.
Netherlands, Rotterdam
Erasmus Mc
Gasparini, Paolo P.
Italy, Trieste
Università Degli Studi Di Trieste
Italy, Trieste
Irccs Burlo Garofolo
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Girotto, Giorgia G.
Italy, Trieste
Università Degli Studi Di Trieste
Italy, Trieste
Irccs Burlo Garofolo
Gottesman, Omri
Unknown Affiliation
Gudnason, V. G.
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Gyllensten, Ulf B.
Sweden, Uppsala
Uppsala Universitet
Harris, Tamara B.
United States, Bethesda
National Institute on Aging Nia
Helmer, Catherine
France, Bordeaux
Bordeaux Population Health Research Center Bph
France, Bordeaux
Université de Bordeaux
Hofer, Edith
Austria, Graz
Medizinische Universität Graz
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Holliday, Elizabeth G.
Australia, Newcastle
Hunter Medical Research Institute, Australia
Homuth, Georg
Germany, Greifswald
Universitätsmedizin Greifswald
Hu, Frank B.
United States, Boston
Channing Division of Network Medicine
Hutri-Kähönen, Nina
Finland, Tampere
Tampere University
Hwang, Shihjen
United States, Framingham
Framingham Heart Study
Imboden, Medea
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Johansson, Åsa K.
Sweden, Uppsala
Uppsala Universitet
Kähönen, Mika A.P.
Finland, Tampere
University Hospital of Tampere
Finland, Tampere
Tampere University
Kramer, Holly J.Mattix
United States, Chicago
Loyola University Chicago
Krämer, Bernhard Karl
Germany, Heidelberg
Universität Heidelberg
Kumar, Ashish Madan
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Sweden, Stockholm
Karolinska Institutet
Kutalik, Zoltán
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Lambert, Jean Charles
France, Lille
Institut Pasteur de Lille
Launer, Lenore J.
United States, Bethesda
National Institute on Aging Nia
Lehtimäki, Terho J.
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
De Borst, Martin H.
Netherlands, Groningen
Rijksuniversiteit Groningen
Navis, Gerjan
Netherlands, Groningen
Rijksuniversiteit Groningen
Swertz, Morris A.
Netherlands, Groningen
Rijksuniversiteit Groningen
Liu, Yongmei
United States, Winston Salem
Wake Forest University School of Medicine
Lohman, Kurt K.
United States, Winston Salem
Wake Forest University School of Medicine
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Lu, Yingchang
Unknown Affiliation
Lyytikäinen, Leo Pekka
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
McEvoy, Mark A.
Australia, Callaghan
The University of Newcastle, Australia
Meisinger, Christa
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Metzger, Marie
France, Gif-sur-yvette
Université Paris-saclay
Mihailov, Evelin
Estonia, Tartu
Tartu Ülikool
Mitchell, Paul G.
Australia, Parramatta
The Westmead Institute for Medical Research
Nauck, Matthias A.
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Oldehinkel, Albertine J.(Tineke)
Netherlands, Groningen
Rijksuniversiteit Groningen
Olden, Matthias
Germany, Regensburg
Universität Regensburg
United States, Framingham
Framingham Heart Study
Penninx, Brenda W. J. H.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Pistis, Giorgio
Italy, Milan
Irccs Ospedale San Raffaele
Pramstaller, Peter P.
Italy, Bolzano
Eurac Research
Probst-Hensch, Nicole M.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Raitakari, Olli T.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Finland, Turku
Turun Yliopisto
Rettig, Rainer
Germany, Greifswald
Universitätsmedizin Greifswald
Ridker, Paul M.
United States, Boston
Harvard Medical School
Rivadeneira, Fernando F.
Netherlands, Rotterdam
Erasmus Mc
Robino, Antonietta
Italy, Trieste
Irccs Burlo Garofolo
Ruderfer, Douglas M.
Unknown Affiliation
Ruggiero, Daniela
Italy, Rome
Consiglio Nazionale Delle Ricerche
Saba, Yasaman
Austria, Graz
Medizinische Universität Graz
Sala, Cinzia Felicita
Italy, Milan
Irccs Ospedale San Raffaele
Schmidt, Helena
Austria, Graz
Medizinische Universität Graz
Schmidt, Reinhold T.
Austria, Graz
Medizinische Universität Graz
Scott, Rodney J.
Australia, Callaghan
The University of Newcastle, Australia
Sedaghat, Sanaz
Netherlands, Rotterdam
Erasmus Mc
Smith, Albert Vernon
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Sorice, Rossella
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Pozzilli
Istituto Neurologico Mediterraneo Neuromed, Pozzilli
Stengel, Brian Né Dicte
France, Gif-sur-yvette
Université Paris-saclay
Strauch, Konstantin
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Toniolo, Daniela
Italy, Milan
Irccs Ospedale San Raffaele
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Ulivi, Sheila
Italy, Trieste
Irccs Burlo Garofolo
Viikari, Jorma S.A.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Finland, Turku
Turun Yliopisto
Völker, Uwe
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Vollenweider, Peter K.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Völzke, Henry
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Vuckovic, Dragana
Italy, Trieste
Università Degli Studi Di Trieste
Italy, Trieste
Irccs Burlo Garofolo
Waldenberger, Melanie
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Wang, Jiejin Jie J.
Australia, Parramatta
The Westmead Institute for Medical Research
Yang, Qiong
United States, Boston
School of Public Health
Chasman, Daniel I.
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Tromp, Gerard C.
United States, Danville
Geisinger Medical Center
Snieder, Harold
Netherlands, Groningen
Rijksuniversiteit Groningen
Heid, Iris Maria
Germany, Regensburg
Universität Regensburg
Fox, Caroline S.
United States, Framingham
Framingham Heart Study
Köttgen, Anna
Germany, Freiburg Im Breisgau
Universität Freiburg
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Pattaro, Cristian
Italy, Bolzano
Eurac Research
Böger, Carsten Alexander
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Fuchsberger, Christian
Italy, Bolzano
Eurac Research
Statistics
Citations: 85
Authors: 118
Affiliations: 60
Identifiers
Doi:
10.1038/srep45040
ISSN:
20452322
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Approach
Systematic review