Bioactive glasses are a part of biomaterials that became an essential in medical applications such as bone repair, bioactive coverings in orthopedic, and dental. In this paper, the radiation transmission properties of CaF2–CaO–B2O3–P2O5:CoO glasses mixed with different therapeutically active ions, viz., Ba2+, Sr2+, Mg2+, and Zn2+ were investigated carrying out the Monte Carlo method (via FLUKA) at the energies of medical interest. The maximum transmission factors determined by HVLs were observed at 10 MeV with the values of 11.7447 cm, 10.9065 cm, 11.3509 cm, 11.6030 cm, and 11.9817 cm for CFCBPC0, CFCBPC1, CFCBPC2, CFCBPC3, and CFCBPC4, respectively. Gamma dose rates of CFCBPC1 are among 5.46 × 106–1.11 × 108 R/h, 1.09 × 106–2.22 × 107 R/h, 5.46 × 105–1.11 × 107, and 3.64 × 105–7.39 × 106 R/f for 1, 5, 10, and 15 mm, respectively. Moreover, the transmission features of the present bioactive glasses were studied against different fields of radiations such as neutrons and charged particles. The validation of Monte Carlo simulations was theoretically proved by employing XCOM calculations. Therefore, this study suggests FLUKA as a promising approach for further studies in materials scenices, especially those related to radiation and medical physics.
