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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer
Nature Genetics, Volume 40, No. 6, Year 2008
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Description
We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 × 10-12 for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer. © 2008 Nature Publishing Group.
Authors & Co-Authors
Stacey, Simon N.
Iceland, Reykjavik
Decode Genetics
Manolescu, Andrei
Iceland, Reykjavik
Decode Genetics
Sulem, Patrick
Iceland, Reykjavik
Decode Genetics
Thorlacius, Steinunn
Iceland, Reykjavik
Decode Genetics
Gudjonsson, Sigurjon A.
Iceland, Reykjavik
Decode Genetics
Jonsson, Gudbjörn F.
Iceland, Reykjavik
Decode Genetics
Jakobsdottir, Margret
Iceland, Reykjavik
Decode Genetics
Bergthorsson, Jon Thor
Iceland, Reykjavik
Decode Genetics
Gudmundsson, Julius
Iceland, Reykjavik
Decode Genetics
Aben, Katja K.H.
Netherlands, Nijmegen
Integraal Kankercentrum Oost
Netherlands, Nijmegen
Radboud University Medical Center
Strobbe, Luc J.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Swinkels, Dorine W.
Netherlands, Nijmegen
Radboud University Medical Center
Van Engelenburg, K. C.Anton
Netherlands, Doetinchem
Slingeland Ziekenhuis
Henderson, Brian E.
United States, Los Angeles
Keck School of Medicine of Usc
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi Cancer Center
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Millastre, Esther
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Andrés, Raquel
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Saez, Berta
Spain, Zaragoza
Institute of Research of Aragón
Lambea, Julio
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Godino, Javier
Spain, Zaragoza
Institute of Research of Aragón
Polo, Eduardo
Spain
Hospital Ernest Lluch
Tres, Alejandro
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Picelli, Simone
Sweden, Stockholm
Karolinska Institutet
Rantala, Johanna
Sweden, Stockholm
Karolinska Institutet
Margolin, Sara J.
Sweden, Stockholm
Södersjukhuset
Jonsson, Thorvaldur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Sigurdsson, Helgi
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Jonsdottir, Thora
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Hrafnkelsson, Jon
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Johannsson, Jakob
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Sveinsson, Thorarinn
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Myrdal, Gardar
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Grimsson, Hlynur Niels
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Sveinsdottir, Steinunn G.
Iceland, Reykjavik
Clinical Research Centre
Alexiusdottir, Kristin
Iceland, Reykjavik
Clinical Research Centre
Saemundsdottir, Jona
Iceland, Reykjavik
Decode Genetics
Sigurdsson, Asgeir
Iceland, Reykjavik
Decode Genetics
Kostic, Jelena Pop
Iceland, Reykjavik
Decode Genetics
Gudmundsson, Larus
Iceland, Reykjavik
Decode Genetics
Kristjansson, Kristleifur
Iceland, Reykjavik
Decode Genetics
Másson, Gísli
Iceland, Reykjavik
Decode Genetics
Fackenthal, James D.
United States, Chicago
The University of Chicago
Adebamowo, Clement
Nigeria, Ibadan
University College Hospital, Ibadan
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University College Hospital, Ibadan
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Haiman, Christopher A.
United States, Los Angeles
Keck School of Medicine of Usc
Lindblöm, Annika
Sweden, Stockholm
Karolinska Institutet
Mayordomo, Jose I.
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Integraal Kankercentrum Oost
Netherlands, Nijmegen
Radboud University Medical Center
Gulcher, Jeffrey Robert
Iceland, Reykjavik
Decode Genetics
Rafnar, Thorunn
Iceland, Reykjavik
Decode Genetics
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Jóhannsson, Óskar Th
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Kong, Augustine
Iceland, Reykjavik
Decode Genetics
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Statistics
Citations: 491
Authors: 56
Affiliations: 16
Identifiers
Doi:
10.1038/ng.131
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Cancer
Genetics And Genomics