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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice
International Journal of Biochemistry and Cell Biology, Volume 44, No. 6, Year 2012
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Description
Epinephrine is one of the major hormones involved in glucose counter-regulation and gluconeogenesis. However, little is known about its importance in energy homeostasis during fasting. Our objective is to study the specific role of epinephrine in glucose and lipid metabolism during starvation. In our experiment, we subject regular mice and epinephrine-deficient mice to a 48-h fast then we evaluate the different metabolic responses to fasting. Our results show that epinephrine is not required for glucose counter-regulation: epinephrine-deficient mice maintain their blood glucose at normal fasting levels via glycogenolysis and gluconeogenesis, with normal fasting-induced changes in the peroxisomal activators: peroxisome proliferator activated receptor γ coactivator α (PGC-1α), fibroblast growth factor 21 (FGF-21), peroxisome proliferator activated receptor α (PPAR-α), and sterol regulatory element binding protein (SREBP-1c). However, fasted epinephrine-deficient mice develop severe ketosis and hepatic steatosis, with evidence for inhibition of hepatic autophagy, a process that normally provides essential energy via degradation of hepatic triglycerides during starvation. We conclude that, during fasting, epinephrine is not required for glucose homeostasis, lipolysis or ketogenesis. Epinephrine may have an essential role in lipid handling, possibly via an autophagy-dependent mechanism. © 2012 Elsevier Ltd.
Authors & Co-Authors
Sharara-Chami, Rana
United States, Boston
Boston Children's Hospital
Lebanon, Beirut
American University of Beirut Medical Center
Zhou, Yingjiang
United States, Boston
Boston Children's Hospital
Ebert, Steven
United States, Orlando
University of Central Florida
Pacak, Karel
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Ozcan, Umut
United States, Boston
Boston Children's Hospital
Majzoub, Joseph A.
United States, Boston
Boston Children's Hospital
Statistics
Citations: 18
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.biocel.2012.02.016
ISSN:
13572725
e-ISSN:
18785875
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative