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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control
European Journal of Immunology, Volume 39, No. 10, Year 2009
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Description
Monocytes and macrophages are target cells for dengue infection. Besides their potential role for virus replication, activated monocytes/macrophages produce cytokines that may be critical for dengue pathology. To study the in vivo role of monocytes and macrophages for virus replication, we depleted monocytes and macrophages in IFN-αβγR knockout mice with clodronate liposomes before dengue infection. Although less virus was first recovered in the draining LN in the absence of macrophages, monocyte/macrophage depletion eventually resulted in a ten-fold higher systemic viral titer. A massive infiltration of CD11b+CD11clowLy6Clow monocytes into infected organs was observed in parallel with increasing virus titers before viremia was controlled. Depletion of monocytes in the blood before or after local infection had no impact on virus titers, suggesting that monocytes are not required as "virus-shuttles". Our data provide evidence that systemic viremia is established independently of tissue macrophages present at the site of infection and blood monocytes. Instead, we demonstrate the importance of monocytes/macrophages for the control of dengue virus. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Fink, Katja
Singapore, Singapore City
Novartis Institute for Tropical Diseases Pte. Ltd.
Singapore, Singapore City
A-star, Singapore Immunology Network
Ng, Cedrig
Singapore, Singapore City
Novartis Institute for Tropical Diseases Pte. Ltd.
Nkenfou, Céline Nguefeu
Singapore, Singapore City
Novartis Institute for Tropical Diseases Pte. Ltd.
Cameroon, Yaounde
Molecular Biology Center
Cameroon, Yaounde
Université de Yaoundé I
Vasudevan, Subhash G.
Singapore, Singapore City
Novartis Institute for Tropical Diseases Pte. Ltd.
Singapore, Singapore City
Duke-nus Medical School
Van-Rooijen, Nico
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Schul, Wouter
Singapore, Singapore City
Novartis Institute for Tropical Diseases Pte. Ltd.
Statistics
Citations: 71
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1002/eji.200939389
e-ISSN:
15214141
Research Areas
Infectious Diseases