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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Schistosomiasis and HIV-1 infection in rural Zimbabwe: Implications of coinfection for excretion of eggs
Journal of Infectious Diseases, Volume 191, No. 8, Year 2005
Notification
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Description
Background. Stunted development and reduced fecundity of Schistosoma parasites in immunodeficient mice and the impaired ability of human immunodeficiency virus 1 (HIV-1)-infected humans to excrete schistosome eggs have been described. This study explores the effect that HIV-1-associated immunodeficiency has on the excretion of schistosome eggs in a large cohort of coinfected individuals. Methods. In a cross-sectional survey, urine and stool samples were obtained from and HIV-1 status was determined for 1545 individuals. More extensive data, including quantitative measures of intensity of infection in schistosomiasis and immunodeficiency, were collected in the Mupfure schistosomiasis and HIV longitudinal cohort, composed of 379 participants of whom 154 were coinfected with HIV-1 and Schistosoma parasites. Results. In the cross-sectional survey, the overall prevalence of schistosomiasis was 43.4%, and 26.3% of the participants were infected with HIV-1. Schistosome infections were due to Schistosoma haematobium in 63.6% of cases, S. mansoni in 18.1% of cases, and dual infections in 18.4% of cases. Intensities of Schistosoma infections, measured by the number of eggs excreted and by the level of circulating anodic antigens, did not differ between HIV-1-negative and HIV-1-positive participants coinfected with S. haematobium, S. mansoni, or both. CD4 cell counts were significantly lower in HIV-1-positive participants and in S. mansoni-infected HIV-1-negative participants than in other participants. Conclusion. The present study suggests that adult HIV-1-related immunodeficiency does not impair the ability to excrete eggs in low-intensity infection with S. haematobium, S. mansoni, or both and that infection with HIV-1 may not have major implications for diagnosis and surveillance of schistosomiasis. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Kallestrup, Per
Unknown Affiliation
Zinyama, Rutendo B.
Unknown Affiliation
Gomo, Exnevia
Unknown Affiliation
Butterworth, Anthony E.
Unknown Affiliation
van Dam, Govert Jan
Unknown Affiliation
Erikstrup, Christian
Unknown Affiliation
Ullum, Henrik
Unknown Affiliation
Statistics
Citations: 75
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1086/428907
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Zimbabwe