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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protection of sheep against Rift Valley fever virus and sheep poxvirus with a recombinant capripoxvirus vaccine
Clinical and Vaccine Immunology, Volume 17, No. 12, Year 2010
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Description
Rift Valley fever (RVF) is an epizootic viral disease of sheep that can be transmitted from sheep to humans, particularly by contact with aborted fetuses. A capripoxvirus (CPV) recombinant virus (rKS1/RVFV) was developed, which expressed the Rift Valley fever virus (RVFV) Gn and Gc glycoproteins. These expressed glycoproteins had the correct size and reacted with monoclonal antibodies (MAb) to native glycoproteins. Mice vaccinated with rKS1/RVFV were protected against RVFV challenge. Sheep vaccinated with rKS1/RVFV twice developed neutralizing antibodies and were significantly protected against RVFV and sheep poxvirus challenge. These findings further document the value of CPV recombinants as ruminant vaccine vectors and support the inclusion of RVFV genes encoding glycoproteins in multivalent recombinant vaccines to be used where RVF occurs. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Soi, Reuben K.
Kenya, Nairobi
Kenya Agricultural Research Institute
Rurangirwa, Fred R.
United States, Pullman
Washington State University Pullman
McGuire, Travis C.
United States, Pullman
Washington State University Pullman
Rwambo, Paul M.
United States, Fort Collins
Colorado State University
Kenya, Nairobi
Food and Agriculture Organization, Kenya
DeMartini, James C.
United States, Fort Collins
Colorado State University
Crawford, Timothy B.
United States, Pullman
Washington State University Pullman
United States
Grays Harbor Veterinary Services
Statistics
Citations: 53
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1128/CVI.00220-10
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Infectious Diseases