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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants
European Journal of Pharmacology: Environmental Toxicology and, Volume 293, No. 1, Year 1995
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Description
A scientific evaluation was made of functionalspects of developmental toxicity of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in experimental animals and in human infants. Persistent neurobehavioral, reproductive and endocrine alterations were observed in experimental animals, following in utero and lactational exposure to PCBs, PCDDs and PCDFs. The lowest observable adverse effect levels (LOAELs) for developmental neurobehavioral and reproduction endpoints, based on bodyen of TCDD-toxic equivalents (TEQs) in animals, are within the range of current background human body burdens. Relatively subtle adverse effects on neurobehavioral development and thyroid hormone alterations have also been observed in infants and children exposed to background levels. Exclusive use of the toxic equivalency factor (TEF) approach may underestimate the risk of neurodevelopmental effects, because both Ah receptor dependent and independent mechanisms may be involved in these effects. The use of marker congeners and/or bioassays based on Ah receptor mediated mechanisms are rapid, low cost pre-screening alternatives for expensive and time consuming gas chromatographic-mass spectrometric analysis. © 1995.
Authors & Co-Authors
Brouwer, Abraham A.
Netherlands, Wageningen
Wageningen University & Research
van den Berg, Martin
Netherlands, Utrecht
Universiteit Utrecht
Birnbaum, Linda S.
United States, Washington, D.c.
United States Environmental Protection Agency
Denison, Michael Steven
United States, Davis
University of California, Davis
Huisman, Marcel
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Jacobson, Sandra W.
United States, Detroit
Wayne State University
Jacobson, Joseph L.
United States, Detroit
Wayne State University
Koopman-Esseboom, Corine M.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Sauer, Pieter Jan Jacob
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Statistics
Citations: 242
Authors: 9
Affiliations: 15
Identifiers
Doi:
10.1016/0926-6917(95)90015-2
ISSN:
09266917
Research Areas
Environmental
Maternal And Child Health
Sexual And Reproductive Health