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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
World Journal of Men's Health, Volume 41, No. 4, Year 2023
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Description
Purpose: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method Results: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated. Conclusions: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians. © The Author(s), 2023.
Authors & Co-Authors
Farkouh, Ala'A N.
Unknown Affiliation
Agarwal, Ashok K.
United States, Cleveland
Cleveland Clinic Foundation
Abdel-Meguid Hamoda, Taha Abo Almagd
Saudi Arabia, Jeddah
King Abdulaziz University
Egypt, Minya
Minia University
Kavoussi, Parviz Keikhosrow
Unknown Affiliation
Saleh, Ramadan Abdou
Egypt, Sohag
Sohag University
Egypt, Sohag
Ajyal Hospital
Zini, Armand S.
Canada, Montreal
Université Mcgill
Arafa, Mohamed Mostafa
Qatar, Doha
Hamad Medical Corporation
Egypt, Giza
Cairo University
Qatar, Doha
Weill Cornell Medicine-qatar
Harraz, Ahmed M.
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Kuwait, Safat
Farwania Hospital
Kuwait, Kuwait City
Sabah al Ahmad Urology Center
Gul, Murat
Turkey, Selçuklu
Selçuk Üniversitesi
Karthikeyan, Vilvapathy Senguttuvan
India, Chennai
Apollo Hospitals Group
Durairajanayagam, Damayanthi
Malaysia, Shah Alam
Universiti Teknologi Mara
Rambhatla, Amarnath
United States, Detroit
Henry Ford Health System
Boitrelle, Florence
France, Poissy
Centre Hospitalier Intercommunal Poissy-st-germain-en-laye
France, Jouy-en-josas
Unité Biologie de la Reproduction, Environnement, Epigénétique et Développement
Chung, Eric
Australia, Woolloongabba
Princess Alexandra Hospital
Birowo, Ponco
Indonesia, Depok
Universitas Indonesia
Toprak, Tuncay
Turkey, Istanbul
University of Health Sciences
Abou Ghayda, Ramy
United States, Cleveland
Case Western Reserve University
Cannarella, Rossella
Italy, Catania
Università Degli Studi Di Catania
United States, Cleveland
Cleveland Clinic Foundation
Phuoc, Nguyen Ho Vinh
Viet Nam, Ho Chi Minh City
Pham Ngoc Thach University of Medicine
Dimitriadis, Fotios
Greece, Thessaloniki
Aristotle University of Thessaloniki
Russo, Giorgio Ivan
Italy, Catania
Università Degli Studi Di Catania
Sokolakis, Ioannis
Greece, Thessaloniki
Aristotle University of Thessaloniki
Mostafa, Taymour M.
Egypt, Giza
Cairo University
Makarounis, Konstantinos
Unknown Affiliation
Ziouziou, Imad
Morocco, Agadir
Université Ibn Zohr
Kuroda, Shinnosuke No Suke
United States, Cleveland
Cleveland Clinic Foundation
Bendayan, Marion
France, Poissy
Centre Hospitalier Intercommunal Poissy-st-germain-en-laye
Simopoulou, Mara C.
Greece, Athens
National and Kapodistrian University of Athens
Rocco, L.
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Garrido, Nicolás
Spain, Valencia
Instituto de Investigación Sanitaria la fe
Gherabi, Nazim
Algeria, Algiers
Université D’alger 1
Böcü, Kadir
Unknown Affiliation
Kahraman, Oğuzhan
Turkey, Ankara
Başkent Üniversitesi
Le, Tan V.
Viet Nam, Ho Chi Minh City
Pham Ngoc Thach University of Medicine
Wyns, Christine
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Tremellen, Kelton P.
Australia, Adelaide
Flinders University
Sarikaya, Selcuk
Turkey, Ankara
Gülhane Eğitim ve Araştırma Hastanesi
Lewis, Sheena E.M.
Unknown Affiliation
Evenson, Donald P.
Unknown Affiliation
Ko, Edmund Yuey Kun
United States, Loma Linda
Loma Linda University Health
Calogero, Aldo E.
Italy, Catania
Università Degli Studi Di Catania
Bahar, Fahmi
Unknown Affiliation
Martínez, Marlon P.
Philippines, Manila
University of Santo Tomas Hospital
Crafa, Andrea
Italy, Catania
Università Degli Studi Di Catania
Nguyen, Quang
Viet Nam, Hanoi
Vietnam National University, Hanoi
Ambar, Rafael Favero
Unknown Affiliation
Colpi, Giovannimaria
Switzerland, Lugano
Next Fertility Procrea
Bakircioǧlu, Mustafa Emre
Unknown Affiliation
Henkel, Ralf Reinhold
United Kingdom, London
Imperial College London
South Africa, Bellville
University of the Western Cape
Kandil, Hussein
Unknown Affiliation
Serefoglu, E. C.
Turkey, Istanbul
Biruni Üniversitesi
Alarbid, Abdullah
Kuwait, Safat
Farwania Hospital
Tsujimura, Akira
Japan, Urayasu
Juntendo Urayasu Hospital
Anagnostopoulou, Christina
Unknown Affiliation
Marino, Angelo
Unknown Affiliation
Adamyan, Aram
Unknown Affiliation
Žilaitiené, Birute
Lithuania, Kaunas
Lietuvos Sveikatos Mokslų Universitetas
Ozer, Cevahir
Turkey, Ankara
Başkent Üniversitesi
Pescatori, Edoardo Stefano
Unknown Affiliation
Vogiatzi, Paraskevi
Unknown Affiliation
Busetto, Gian Maria
Italy, Foggia
Università Degli Studi Di Foggia
Balercia, Giancarlo
Italy, Ancona
Università Politecnica Delle Marche
Akhavizadegan, Hamed
Iran, Tehran
Tehran University of Medical Sciences
Sajadi, Hesamoddin
Iran, Tehran
Iranian Academic Center for Education, Culture and Research
Taniguchi, Hisanori
Japan, Hirakata
Kansai Medical University
Park, Hyunjun
South Korea, Busan
Pusan National University
South Korea, Busan
Pusan National University Hospital
Rosas, Israel Maldonado
Unknown Affiliation
Al-Marhoon, Mohammed Salim
Oman, Muscat
Sultan Qaboos University
Pinggera, Germar Michael
Austria, Innsbruck
Medizinische Universitat Innsbruck
Kothari, Priyank
Unknown Affiliation
Mogharabian, Nasser
Iran, Shahrood
Shahroud University of Medical Sciences
Mićić, Sava R.
Unknown Affiliation
Homa, Sheryl T.
United Kingdom, Canterbury
University of Kent
Darbandi, Sara
Iran, Tehran
Hope Generation Foundation
Long, Tran Quang Tien
Viet Nam, Hanoi
Hanoi Obstetrics and Gynecology Hospital
Zohdy, Wael Ahmed
Egypt, Giza
Cairo University
Atmoko, Widi
Indonesia, Depok
Universitas Indonesia
Sabbaghian, Marjan
Iran, Tehran
Iranian Academic Center for Education, Culture and Research
Ibrahim, Wael
Egypt, Cairo
Fertility Care Center in Cairo
Smith, Ryan P.
United States, Charlottesville
University of Virginia
Ho, Christopher Chee Kong
Malaysia, Subang Jaya
Taylor's University Malaysia
de la Rosette, Jean Jmch
Turkey, Istanbul
İstanbul Medipol Üniversitesi
El-Sakka, Ahmed I.
Egypt, Ismailia
Suez Canal University
Preto, Mirko
Italy, Turin
Università Degli Studi Di Torino
Zenoaga-Barbăroșie, Cătălina
Romania, Bucharest
Universitatea Din Bucuresti
Abumelha, Saad Mohammed
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Başer, Aykut
Turkey, Bandirma
Bandırma Onyedi Eylül University
Aydos, Kaan
Turkey, Ankara
Ankara Üniversitesi
Ong, Teng Aik
Malaysia, Kuala Lumpur
Universiti Malaya
Mierzwa, Tiago César
Unknown Affiliation
Adriansjah, Ricky
Indonesia, Bandung
Universitas Padjadjaran
Banihani, Saleem Ali
Jordan, Irbid
Jordan University of Science and Technology
Bowa, Kasonde
Zambia, Lusaka
University of Lusaka
Peña, Marcelo Rodriguez
Unknown Affiliation
Moussa, Mohamad Ahmad
Lebanon, Beirut
Université Libanaise
Cho, Chak Lam
Hong Kong, Hong Kong
Chinese University of Hong Kong
Tadros, Nicholas N.
United States, Carbondale
Southern Illinois University Carbondale
Ugur, Muhammet Rasit
Unknown Affiliation
Amar, Édouard T.
France, Neuilly-sur-seine
Hôpital Américain de Paris
Falcone, Marco
Italy, Turin
Azienda Ospedaliera - Universitaria Città Della Salute e Della Scienza Di Torino
Kalkanlı, Arif
Turkey, Istanbul
T. C. Sağlık Bakanlığı, Taksim Eğitim ve Araştirma Hastanesi
Khalafalla, Kareim
Qatar, Doha
Hamad Medical Corporation
United States, Houston
University of Texas Health Science Center at Houston
United States, Houston
The University of Texas Md Anderson Cancer Center
Finocchi, Federica
Italy, Ancona
Università Politecnica Delle Marche
Giulioni, Carlo
Italy, Ancona
Università Politecnica Delle Marche
Ceyhan, Erman
Turkey, Ankara
Başkent Üniversitesi
Çeker, Gökhan
Unknown Affiliation
Yazbeck, Chadi M.
Unknown Affiliation
Rajmil, Osvaldo
Spain, Barcelona
Fundacio Puigvert
Barrett, Trenton L.
Unknown Affiliation
Roychoudhury, Shubhadeep
India, Silchar
Assam University
Salvio, Gianmaria
Italy, Ancona
Università Politecnica Delle Marche
Lin, Haocheng
China, Beijing
Peking University Third Hospital
Kadıoğlu, Ateş
Turkey, Istanbul
Istanbul Üniversitesi
Timpano, Massimiliano
Italy, Turin
Azienda Ospedaliera - Universitaria Città Della Salute e Della Scienza Di Torino
Hakim, Lukman
Indonesia, Surabaya
Universitas Airlangga
Franco, Giorgio
Italy, Rome
Azienda Ospedaliera Universitaria Policlinico Umberto I
Singh, Rajender R.
India, Lucknow
Central Drug Research Institute India
Kosgi, Raghavender
Unknown Affiliation
Sofikitis, Nikolaos V.
Greece, Ioannina
University of Ioannina
Palani, Ayad F.
Iraq, Kalar City
University of Garmian
Çalik, Gökhan
Turkey, Istanbul
İstanbul Medipol Üniversitesi
Kulaksiz, Deniz
Turkey, Istanbul
University of Health Sciences
Drakopoulos, Panagiotis
Belgium, Brussels
Vrije Universiteit Brussel
Greece, Athens
Ivf Athens Center
Ramsay, Jonathan W.A.
United Kingdom, London
Hammersmith Hospital
Amano, Toshiyasu
Unknown Affiliation
Söǧütdelen, Emrullah
Turkey, Bolu
Bolu Abant İzzet Baysal Üniversitesi
Duarsa, Gede Wirya Kusuma
Indonesia, Bali
Universitas Udayana
Chiba, Koji
Japan, Kobe
Kobe University
Jindal, Sunil K.
India, Meerut
Jindal Hospital
Savira, Missy
Indonesia, Depok
Universitas Indonesia
Boeri, Luca
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Borges, Edson
Unknown Affiliation
Gökalp, Fatih
Turkey, Antakya
Mustafa Kemal Üniversitesi
Minhas, Suks S.
United Kingdom, London
Imperial College London
Shah, Rupin
Unknown Affiliation
Statistics
Citations: 6
Authors: 135
Affiliations: 111
Identifiers
Doi:
10.5534/wjmh.230008
ISSN:
22874208
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male