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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human immunodeficiency virus type 1 IgA antibody in breast milk and serum
Pediatric Infectious Disease Journal, Volume 13, No. 7, Year 1994
Notification
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Description
Breast-feeding plays a potentially significant role in mother to child transmission of human immunodeficiency virus type 1 (HIV-1). The additional transmission risk attributable to breast-feeding and the factors that enhance or inhibit transmission are presently unknown. One mechanism by which breast milk might inhibit HIV-1 transmission is the presence of specific antibodies directed against HIV-1 in breast milk of seropositive mothers. In this study serum and breast milk samples from women in Nairobi, Kenya, were tested to determine the prevalence of HIV-1 IgA antibodies. A Western blot test developed in our laboratory was used to detect anti-HIV-1 immunoglobulin A in serum and anti-HIV-1 secretory IgA (slgA) in breast milk. Ninety-four percent of 63 HIV-1 seropositive women had anti-HIV-1 IgA in serum and 59% had anti-HIV-1 slgA in their breast milk. No significant associations with maternal characteristics or serum anti-HIV-1 IgA or IgG banding patterns and the presence of anti-HIV- 1 slgA in breast milk were found. No protective effect of anti-HIV-1 slgA was seen regarding mother to child transmission; however, further studies are necessary to determine the effect of these antibodies in maternal sera or in breast milk on the efficacy of HIV-1 transmission. © 1994 by Williams & Wilkins.
Authors & Co-Authors
Duprat, Christine
Canada, Winnipeg
University of Manitoba
Mohammed, Zeena
Canada, Winnipeg
University of Manitoba
Datta, Pratibha
Kenya, Nairobi
University of Nairobi
Stackiw, Walter
Canada, Winnipeg
Cadham Provincial Laboratory
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Kreiss, Joan K.
Kenya, Nairobi
University of Nairobi
United States, Seattle
University of Washington
Holmes, King K.
Kenya, Nairobi
University of Nairobi
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Embreé, Joanne E.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 38
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/00006454-199407000-00004
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Kenya
Participants Gender
Female