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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic polymorphism of glutathione S-transferases M1 and T1 in Egyptian patients with bilharzial bladder cancer
Urologic Oncology: Seminars and Original Investigations, Volume 28, No. 3, Year 2010
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Description
Objective: To assess the influence of glutathione S-transferases M1 and T1 (GSTM1 and T1) genotype on the risk of bladder cancer in patients with urinary bilharziasis. Materials and methods: This study was designed as a case-control study that involved 60 individuals who were enrolled into 3 equal groups. The first one included patients with bilharzial bladder cancer, the second one had those with nonmalignant urinary bilharziasis, and the last one was the control group. All of the participants were adult males, nonsmokers, and with matched ages. All of them underwent an assessment of the serum level of the total GST concentration and the polymerase chain reaction (PCR) was used for determination of the GSTM1 and T1 genotypes. Results: The lower most GST enzyme concentration was reported in patients with bilharzial bladder cancer (26 ± 4.4 ng/ml) with significant difference between it and that of the second group (36.8 ± 4.1 ng/ml, P < 0.05) and that of the controls (40.4 ± 4 ng/ml, P < 0.005). The PCR results have demonstrated that the frequency of combined GSTM1 and T1 genes deletion (M1-ve T1-ve) was significantly higher in cases of bladder cancer (40%) than those of the controls (5%, P < 0.005) and those of the second group (10%, P < 0.05). The unconditional logistic regression test revealed that patients with urinary bilharziasis and combined GSTM1 and T1 genes deletion are at a significant risk for malignant transformation (OR = 6.3, P < 0.05). Conclusions: Patients with urinary bilharziasis and GSTM1-ve and T1-ve genes might be at increased risk of bladder cancer. However, larger studies are needed for confirmation of these results. © 2010 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Abd El Hameed, Amal H.
Egypt, Tanta
Tanta University
Negm, Osama El Sayed
Egypt, Tanta
Tanta University
El-Gamal, Osama Mostafa
Egypt, Tanta
Tanta University
Hamouda, Hala E.
Egypt, Tanta
Tanta University
El-Nouby, Kholoud Abd
Egypt, Tanta
Tanta University
Ismail, Ghada Mahmoud
Egypt, Tanta
Tanta University
Statistics
Citations: 6
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.urolonc.2008.09.015
ISSN:
10781439
Research Areas
Cancer
Genetics And Genomics
Study Design
Randomised Control Trial
Case-Control Study