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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Seminal reactive oxygen species-antioxidant relationship in fertile males with and without varicocele
Andrologia, Volume 41, No. 2, Year 2009
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Description
The aim of this study was to assess seminal reactive oxygen species (ROS)-antioxidants relationship in fertile and infertile men with and without varicocele. One hundred and seventy six males were studied; fertile healthy volunteers (n = 45), fertile men with varicocele (n = 45), infertile oligoasthenozoospermia (OA, n = 44) without varicocele and infertile OA with varicocele (n = 42). In their seminal plasma, two ROS parameters (malondialdehyde, hydrogen peroxide) and five antioxidants (superoxide dismutase, catalase, glutathione peroxidase, vitaminE, vitaminC) were estimated. Compared with fertile healthy men, in all other studied groups, estimated seminal ROS were significantly higher and estimated antioxidants were significantly lower. Infertile men with varicocele showed the same relationship as infertile men without varicocele. Sperm concentration, total sperm motility as well as sperm normal forms were negatively correlated with seminal malondialdehyde and were positively correlated with vitaminC. It is concluded that varicocele has an oxidative stress (OS) in fertile normozoospermic bearing conditions. This may allow understanding that, within men with varicocele, there is a threshold value of OS over which male fertility may be impaired. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Mostafa, Taymour M.
Egypt, Cairo
Faculty of Medicine
Anis, Tarek H.
Egypt, Cairo
Faculty of Medicine
Imam, Hager
Egypt, Giza
Institute of Ophthalmology
Elnashar, Abdelrahman R.M.
Egypt, Cairo
Faculty of Medicine
Osman, Ihab Abdel Latef
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 128
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1439-0272.2008.00900.x
ISSN:
03034569
e-ISSN:
14390272
Research Areas
Sexual And Reproductive Health
Participants Gender
Male