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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis
Journal of Pathology, Volume 237, No. 3, Year 2015
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Description
The purpose of this review is to highlight the recent mechanistic developments elucidating the role of matrix metalloproteinases (MMPs) in tumour invasion and metastasis. The ability of tumour cells to invade, migrate, and subsequently metastasize is a fundamental characteristic of cancer. Tumour invasion and metastasis are increasingly being characterized by the dynamic relationship between cancer cells and their microenvironment and developing a greater understanding of these basic pathological mechanisms is crucial. While MMPs have been strongly implicated in these processes as a result of extensive circumstantial evidence - for example, increased expression of individual MMPs in tumours and association of specific MMPs with prognosis - the underpinning mechanisms are only now being elucidated. Recent studies are now providing a mechanistic basis, highlighting and reinforcing the catalytic and non-catalytic roles of specific MMPs as key players in tumour invasion and metastasis. © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors & Co-Authors
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
Murray, Graeme I.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 196
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1002/path.4586
ISSN:
00223417
Research Areas
Cancer