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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Prenatal alcohol exposure alters the patterns of facial asymmetry
Alcohol, Volume 44, No. 7-8, Year 2010
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Description
Directional asymmetry, the systematic differences between the left and right body sides, is widespread in human populations. Changes in directional asymmetry are associated with various disorders that affect craniofacial development. Because facial dysmorphology is a key criterion for diagnosing fetal alcohol syndrome (FAS), the question arises whether in utero alcohol exposure alters directional asymmetry in the face. Data on the relative position of 17 morphologic landmarks were obtained from facial scans of children who were classified as either FAS or control. Shape data obtained from the landmarks were analyzed with the methods of geometric morphometrics. Our analyses showed significant directional asymmetry of facial shape, consisting primarily of a shift of midline landmarks to the right and a displacement of the landmarks around the eyes to the left. The asymmetry of FAS and control groups differed significantly and average directional asymmetry was increased in those individuals exposed to alcohol in utero. These results suggest that the developmental consequences of fetal alcohol exposure affect a wide range of craniofacial features in addition to those generally recognized and used for diagnosis of FAS. © 2010 Elsevier Inc.
Authors & Co-Authors
Wetherill, Leah Flury
United States, Indianapolis
Indiana University School of Medicine
Rogers, Jeffrey L.
United States, Indianapolis
Indiana University-purdue University Indianapolis
Moore, Elizabeth S.
United States, Indianapolis
St. Vincent Indianapolis Hospital
United States, Indianapolis
Indiana University-purdue University Indianapolis
Ward, Richard E.
United States, Indianapolis
Indiana University-purdue University Indianapolis
Autti-Rämö, Ilona S.
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Social Insurance Institution Helsinki
Fagerlund, Åse
Finland, Helsinki
Folkhälsan
Finland, Turku
Åbo Akademi University
Jacobson, Sandra W.
United States, Detroit
Wayne State University School of Medicine
Robinson, Luther K.
United States, Buffalo
University at Buffalo, the State University of new York
Hoyme, H. Eugene
United States, Sioux Falls
Sanford School of Medicine
Mattson, Sarah N.
United States, San Diego
San Diego State University
Li, Tingkai
United States, Durham
Duke University
Riley, Edward Patrick
United States, San Diego
San Diego State University
Foroud, Tatiana M.
United States, Indianapolis
Indiana University School of Medicine
Statistics
Citations: 82
Authors: 13
Affiliations: 13
Identifiers
Doi:
10.1016/j.alcohol.2009.10.016
ISSN:
07418329
Research Areas
Maternal And Child Health
Substance Abuse