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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phylogenomic analysis of 11 complete African swine fever virus genome sequences
Virology, Volume 400, No. 1, Year 2010
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Description
Viral molecular epidemiology has traditionally analyzed variation in single genes. Whole genome phylogenetic analysis of 123 concatenated genes from 11 ASFV genomes, including E75, a newly sequenced virulent isolate from Spain, identified two clusters. One contained South African isolates from ticks and warthog, suggesting derivation from a sylvatic transmission cycle. The second contained isolates from West Africa and the Iberian Peninsula. Two isolates, from Kenya and Malawi, were outliers. Of the nine genomes within the clusters, seven were within p72 genotype 1. The 11 genomes sequenced comprised only 5 of the 22 p72 genotypes. Comparison of synonymous and non-synonymous mutations at the genome level identified 20 genes subject to selection pressure for diversification. A novel gene of the E75 virus evolved by the fusion of two genes within the 360 multicopy family. Comparative genomics reveals high diversity within a limited sample of the ASFV viral gene pool. © 2010 Elsevier Inc. All rights reserved.
Authors & Co-Authors
De Villiers, Etienne P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Gallardo, Carmina
Spain, Valdeolmos
Csic-inia-cisa - Centro de Investigación en Sanidad Animal
Arias, M.
Spain, Valdeolmos
Csic-inia-cisa - Centro de Investigación en Sanidad Animal
da Silva, Melissa
Canada, Victoria
University of Victoria
Upton, Chris
Canada, Victoria
University of Victoria
Martín, Raquel
Spain, Valdeolmos
Csic-inia-cisa - Centro de Investigación en Sanidad Animal
Bishop, Richard Peter
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 147
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2010.01.019
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Cancer
Genetics And Genomics
Study Locations
Multi-countries
Kenya
Malawi