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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: Experimental study in rats using vascular corrosion casts
Neuroscience Letters, Volume 470, No. 1, Year 2010
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Description
Fasudil (a Rho-kinase inhibitor) has been shown to attenuate abdominal aortic aneurysm development, but any preventive effect against development of cerebral aneurysms is unclear. The effect of fasudil on the development of cerebral aneurysms was investigated in 55 female Sprague-Dawley rats divided into 4 groups: Group 1 (n = 10) was the control group without treatment. Groups 2-4 (n = 15 each) were subjected to cerebral aneurysm induction procedures plus 1% NaCl in the drinking water. Groups 3 and 4 were also treated with 0.5 or 1.0 mg/mL of fasudil in the drinking water, respectively. Vascular corrosion casts of the cerebral arteries were prepared and examined using a scanning electron microscope after 2 months. No significant differences were observed in the degree of induced hypertension between Groups 2, 3 and 4. No aneurysms were found in Group 1. Examination of the left anterior cerebral-olfactory artery junction, which is the most susceptible site for aneurysm development, found significantly fewer aneurysmal lesions in Groups 3 (60%) and 4 (53%) compared to Group 2 (100%) (P < 0.02). This study suggests that fasudil attenuated induction of cerebral aneurysms in the rat model. © 2009 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Eldawoody, Hany A.Fikry
Japan, Sendai
Graduate School of Medicine
Egypt, Mansoura
Faculty of Medicine
Shimizu, Hiroaki
Japan, Sendai
Graduate School of Medicine
Kimura, Naoto
Japan, Sendai
Graduate School of Medicine
Saito, Atsushi
Japan, Sendai
Graduate School of Medicine
Nakayama, Toshio
Japan, Sendai
Tohoku University
Takahashi, Akira
Japan, Sendai
Graduate School of Medicine
Japan, Sendai
Tohoku University
Tominaga, Teiji
Japan, Sendai
Graduate School of Medicine
Statistics
Citations: 14
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.neulet.2009.12.061
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Randomised Control Trial
Participants Gender
Female