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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients
HIV Medicine, Volume 18, No. 1, Year 2017
Notification
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Description
Objectives: The aim of this work was to provide a reference for the CD4 T-cell count response in the early months after the initiation of combination antiretroviral therapy (cART) in HIV-1-infected patients. Methods: All patients in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) cohort who were aged ≥ 18 years and started cART for the first time between 1 January 2005 and 1 January 2010 and who had at least one available measurement of CD4 count and a viral load ≤ 50 HIV-1 RNA copies/mL at 6 months (± 3 months) after cART initiation were included in the study. Unadjusted and adjusted references curves and predictions were obtained using quantile regressions. Results: A total of 28 992 patients were included in the study. The median CD4 T-cell count at treatment initiation was 249 [interquartile range (IQR) 150, 336] cells/μL. The median observed CD4 counts at 6, 9 and 12 months were 382 (IQR 256, 515), 402 (IQR 274, 543) and 420 (IQR 293, 565) cells/μL. The two main factors explaining the variation of CD4 count at 6 months were AIDS stage and CD4 count at cART initiation. A CD4 count increase of ≥ 100 cells/mL is generally required in order that patients stay ‘on track’ (i.e. with a CD4 count at the same percentile as when they started), with slightly higher gains required for those starting with CD4 counts in the higher percentiles. Individual predictions adjusted for factors influencing CD4 count were more precise. Conclusions: Reference curves aid the evaluation of the immune response early after antiretroviral therapy initiation that leads to viral control. © 2016 British HIV Association
Authors & Co-Authors
Bouteloup, Vincent
France, Bordeaux
Centre D'investigation Clinique de Bordeaux 1401 Module Plurithématique
France, Paris
Inserm
Sabin, Caroline Anne
United Kingdom, London
University College London
Mocroft, Amanda A.
United Kingdom, London
University College London
Pantazis, Nikos
Greece, Athens
School of Medicine
Le Moing, Vincent
France, Montpellier
Université de Montpellier
D'Arminio Monforte, Antonella D.
Italy, Milan
Ospedale San Paolo
Mary-Krause, Murielle
France, Paris
Sorbonne Université
France, Paris
Inserm
Roca, B.
Spain, Castellon de la Plana
Hospital General de Castellon
Miró, José Mª
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Berenguer, Juan J.
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Obel, Niels
Denmark, Copenhagen
Copenhagen University Hospital
de Wit, Stéphane A.
Belgium, Brussels
Université Libre de Bruxelles
Zangerle, Robert
Austria, Innsbruck
Medizinische Universitat Innsbruck
Campbell, Maria Athena
Denmark, Copenhagen
Københavns Universitet
Chêne, Geneviève
France, Bordeaux
Centre D'investigation Clinique de Bordeaux 1401 Module Plurithématique
France, Paris
Inserm
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Meyer, Laurence J.
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Dorrucci, Maria
Italy, Rome
Istituto Superiore Di Sanita
Torti, Carlo
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Thíébaut, Rodolphe
Unknown Affiliation
Touloumi, Giota
Unknown Affiliation
Warszawski, Josiane
Unknown Affiliation
Dabis, François
Unknown Affiliation
Leport, Catherine
Unknown Affiliation
Wittkop, Linda
Unknown Affiliation
Reiss, Peter
Unknown Affiliation
Wit, Ferdinand W.N.M.
Unknown Affiliation
Bucher, Heiner C.
Unknown Affiliation
Gibb, Diana M.
Unknown Affiliation
Thorne, Claire N.
Unknown Affiliation
Stephan, Christoph J.
Unknown Affiliation
Hamouda, Osamah
Unknown Affiliation
Gunsenheimer-Bartmeyer, Barbara
Unknown Affiliation
Chkhartishvili, Nikoloz I.
Unknown Affiliation
Noguera-Julián, Antoni Diez
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Prieto, Luis M.
Unknown Affiliation
Conejo, Pablo Rojo
Unknown Affiliation
Soriano-Arandes, Antoni
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Tookey, Pat A.
Unknown Affiliation
Casabona, Jordi
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
Goetghebuer, Tessa
Unknown Affiliation
Sönnerborg, Anders B.
Unknown Affiliation
Teira, Ramón M.
Unknown Affiliation
Garrido, Myriam
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Costagliola, Dominique G.
Unknown Affiliation
Raben, Dorthe
Unknown Affiliation
Barger, Diana
Unknown Affiliation
Colin, Céline
Unknown Affiliation
Schwimmer, Christine
Unknown Affiliation
Termote, Monique
Unknown Affiliation
Friis-Möller, Nina
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
Brandt, Rikke Salbøl
Unknown Affiliation
Bohlius, Julia
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Davies, M. A.
Unknown Affiliation
Dunn, David T.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Guiguet, Marguerite
Unknown Affiliation
Grabar, Sophie G.
Unknown Affiliation
Lambotte, Olivier
Unknown Affiliation
Leroy, Valeriane
Unknown Affiliation
Lodi, Sara
Unknown Affiliation
Matheron, Sophie
Unknown Affiliation
Monge, Susana
Unknown Affiliation
Nakagawa, Fumiyo
Unknown Affiliation
Paredes, Roger
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Schomaker, Michael
Unknown Affiliation
Smit, Colette
Unknown Affiliation
Sterne, Jonathan A.C.
Unknown Affiliation
van der Valk, Marc
Unknown Affiliation
Wyss, Natasha
Unknown Affiliation
Sabin, Caroline A.
United Kingdom, London
University College London
Mocroft, Amanda J.
United Kingdom, London
University College London
Gras, Luuk A.J.
Netherlands, Amsterdam
Stichting Hiv Monitoring
Le-Moing, Vincent
France, Montpellier
Université de Montpellier
d’Arminio-Monforte, Antonella
Italy, Milan
Università Degli Studi Di Milano
Miró, José María
Spain, Barcelona
Hospital Clinic Barcelona
Battegay, Manuel
Switzerland, Basel
Universitätsspital Basel
Brockmeyer, Norbert Hermann
Germany, Bochum
Ruhr-universitat Bochum
Morlat, Philippe
France, Bordeaux
Hopital Saint-andre
Fätkenheuer, Gerd
Germany, Koln
Universität zu Köln
Zangerle, Robert
Austria, Innsbruck
Medizinische Universitat Innsbruck
Ghosn, Jade
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Prins, Maria
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Utrecht
Netherlands Public Health Service
Dorrucci, Maria
Italy, Rome
Istituto Superiore Di Sanita
Statistics
Citations: 15
Authors: 93
Affiliations: 34
Identifiers
Doi:
10.1111/hiv.12389
ISSN:
14642662
Research Areas
Infectious Diseases
Study Design
Cohort Study