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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans
Obesity Surgery, Volume 24, No. 2, Year 2014
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Description
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) reduces appetite and induces significant and sustainable weight loss. Circulating gut hormones changes engendered by LRYGBP are implicated in mediating these beneficial effects. Laparoscopic sleeve gastrectomy (LSG) is advocated as an alternative to LRYGBP, with comparable short-term weight loss and metabolic outcomes. LRYGBP and LSG are anatomically distinct procedures causing differential entero-endocrine cell nutrient exposure and thus potentially different gut hormone changes. Studies reporting the comparative effects of LRYGBP and LSG on appetite and circulating gut hormones are controversial, with no data to date on the effects of LSG on circulating peptide YY3-36 (PYY3-36) levels, the specific PYY anorectic isoform. In this study, we prospectively investigated appetite and gut hormone changes in response to LRYGBP and LSG in adiposity-matched non-diabetic patients. Anthropometric indices, leptin, fasted and nutrient-stimulated acyl-ghrelin, active glucagon-like peptide-1 (GLP-1), PYY3-36 levels and appetite were determined pre-operatively and at 6 and 12 weeks post-operatively in obese, non-diabetic females, with ten undergoing LRYGBP and eight adiposity-matched females undergoing LSG. LRYGBP and LSG comparably reduced adiposity. LSG decreased fasting and post-prandial plasma acyl-ghrelin compared to pre-surgery and to LRYGBP. Nutrient-stimulated PYY3-36 and active GLP-1 concentrations increased post-operatively in both groups. However, LRYGBP induced greater, more sustained PYY3-36 and active GLP-1 increments compared to LSG. LRYGBP suppressed fasting hunger compared to LSG. A similar increase in post-prandial fullness was observed post-surgery following both procedures. LRYGBP and LSG produced comparable enhanced satiety and weight loss. However, LSG and LRYGBP differentially altered gut hormone profiles. © 2013 The Author(s).
Authors & Co-Authors
Yousseif, Ahmed
United Kingdom, London
University College London
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Emmanuel, Julian
United Kingdom, London
University College London
Karra, Efthimia
United Kingdom, London
University College London
Millet, Queensta
United Kingdom, London
University College London
Elkalaawy, Mohamed
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Egypt, Alexandria
Alexandria University
Jenkinson, Andrew
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Hashemi, Majid
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Adamo, Marco
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Finer, Nick
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Fiennes, Alberic G.
United Kingdom, North Cheam
St Anthony's Hospital
Withers, Dominic
United Kingdom, London
Imperial College London
Batterham, Rachel Louise
United Kingdom, London
University College London
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Statistics
Citations: 234
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1007/s11695-013-1066-0
ISSN:
09608923
e-ISSN:
17080428
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases
Participants Gender
Female