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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Widely conserved recombination patterns among single-stranded DNA viruses
Journal of Virology, Volume 83, No. 6, Year 2009
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Description
The combinatorial nature of genetic recombination can potentially provide organisms with immediate access to many more positions in sequence space than can be reached by mutation alone. Recombination features particularly prominently in the evolution of a diverse range of viruses. Despite rapid progress having been made in the characterization of discrete recombination events for many species, little is currently known about either gross patterns of recombination across related virus families or the underlying processes that determine genome-wide recombination breakpoint distributions observable in nature. It has been hypothesized that the networks of coevolved molecular interactions that define the epistatic architectures of virus genomes might be damaged by recombination and therefore that selection strongly influences observable recombination patterns. For recombinants to thrive in nature, it is probably important that the portions of their genomes that they have inherited from different parents work well together. Here we describe a comparative analysis of recombination breakpoint distributions within the genomes of diverse single-stranded DNA (ssDNA) virus families. We show that whereas nonrandom breakpoint distributions in ssDNA virus genomes are partially attributable to mechanistic aspects of the recombination process, there is also a significant tendency for recombination breakpoints to fall either outside or on the peripheries of genes. In particular, we found significantly fewer recombination breakpoints within structural protein genes than within other gene types. Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families. Copyright © 2009, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2648288/bin/supp_83_6_2697__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2648288/bin/supp_83_6_2697__Supplementary_Table_1_dataset_descriptions_121108.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2648288/bin/supp_83_6_2697__Dataset.zip
Authors & Co-Authors
Lefeuvre, Pierre F.
France, Saint-denis
Université de la Réunion
Lett, Jean Michel
France, Saint-denis
Université de la Réunion
Varsani, Arvind
South Africa, Cape Town
University of Cape Town
New Zealand, Christchurch
University of Canterbury
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 229
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.02152-08
ISSN:
0022538X
Research Areas
Cancer
Genetics And Genomics
Health System And Policy