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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Ultrasound-Induced New Cellular Mechanism Involved in Drug Resistance
PLoS ONE, Volume 7, No. 12, Article e48291, Year 2012
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Description
The acoustic effects in a biological milieu offer several scenarios for the reversal of multidrug resistance. In this study, we have observed higher sensitivity of doxorubicin-resistant uterine sarcoma MES-SA/DX5 cells to ultrasound exposure compared to its parent counterpart MES-SA cells; however, the results showed that the acoustic irradiation was genotoxic and could promote neotic division in exposed cells that was more pronounced in the resistant variant. The neotic progeny, imaged microscopically 24 hr post sonication, could contribute in modulating the final cell survival when an apoptotic dose of doxorubicin was combined with ultrasound applied either simultaneously or sequentially in dual-treatment protocols. Depending on the time and order of application of ultrasound and doxorubicin in combination treatments, there was either desensitization of the parent cells or sensitization of the resistant cells to doxorubicin action. © 2012 Hassan et al.
Authors & Co-Authors
Hassan, Mariame Ali
Japan, Toyama
University of Toyama
Egypt, Cairo
Faculty of Pharmacy
Furusawa, Yukihiro
Japan, Toyama
University of Toyama
Minemura, Masami
Japan, Toyama
University of Toyama
Rapoport, Natalya
United States, Salt Lake City
The University of Utah
Sugiyama, Toshiro
Japan, Toyama
University of Toyama
Kondo, Takashi
Japan, Toyama
University of Toyama
Statistics
Citations: 6
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0048291
e-ISSN:
19326203
Research Areas
Cancer