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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Developing Prediction Equations and a Mobile Phone Application to Identify Infants at Risk of Obesity
PLoS ONE, Volume 8, No. 8, Article e71183, Year 2013
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Description
Background:Advancements in knowledge of obesity aetiology and mobile phone technology have created the opportunity to develop an electronic tool to predict an infant's risk of childhood obesity. The study aims were to develop and validate equations for the prediction of childhood obesity and integrate them into a mobile phone application (App).Methods and Findings:Anthropometry and childhood obesity risk data were obtained for 1868 UK-born White or South Asian infants in the Born in Bradford cohort. Logistic regression was used to develop prediction equations (at 6±1.5, 9±1.5 and 12±1.5 months) for risk of childhood obesity (BMI at 2 years >91st centile and weight gain from 0-2 years >1 centile band) incorporating sex, birth weight, and weight gain as predictors. The discrimination accuracy of the equations was assessed by the area under the curve (AUC); internal validity by comparing area under the curve to those obtained in bootstrapped samples; and external validity by applying the equations to an external sample. An App was built to incorporate six final equations (two at each age, one of which included maternal BMI). The equations had good discrimination (AUCs 86-91%), with the addition of maternal BMI marginally improving prediction. The AUCs in the bootstrapped and external validation samples were similar to those obtained in the development sample. The App is user-friendly, requires a minimum amount of information, and provides a risk assessment of low, medium, or high accompanied by advice and website links to government recommendations.Conclusions:Prediction equations for risk of childhood obesity have been developed and incorporated into a novel App, thereby providing proof of concept that childhood obesity prediction research can be integrated with advancements in technology. © 2013 Santorelli et al.
Authors & Co-Authors
Santorelli, Gillian R.
United Kingdom, Bradford
Bradford Royal Infirmary
Petherick, Emily S.
United Kingdom, Bradford
Bradford Royal Infirmary
Wright, John P.
United Kingdom, Bradford
Bradford Royal Infirmary
Cameron, Noel
United Kingdom, Loughborough
Loughborough University
Johnson, William
United Kingdom, London
Medical Research Council
Statistics
Citations: 38
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0071183
ISSN:
19326203
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study