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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Jaundice in Severe Bacterial Infection
Gastroenterology, Volume 71, No. 1, Year 1976
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Description
Thirty patients are described who developed jaundice during the course of severe bacterial infection. Although the infecting organism was variable, as was the site of infection, the patients were generally ill and pyrexial. The group had a very high mortality rate (43%). A positive blood culture was obtained in 11 patients. Biochemical abnormalities noted were those of an increased concentration of conjugated bilirubin in the serum with only a modest increase in alkaline phosphatase and transaminase levels. Serum cholesterol was found to be normal. The mean serum urea level was significantly elevated, as were creatine phosphokinase and lactic dehydrogenase. Most patients exhibited a neutrophil leukocytosis and an elevated sedimentation rate, and the mean hemoglobin level was low. Liver histology was studied in 13 patients. There was evidence of mild bile stasis in 5 and moderate bile stasis in 2. Findings were otherwise nonspecific and were characterized by fatty change and/or inflammatory cells in the portal areas. There was no correlation between degree or duration of jaundice and prognosis, although all patients who died remained jaundiced until death. It is suggested that this syndrome is not one of true cholestasis in that all biliary substances were not shown to be elevated in the serum, but that it is rather a selective defect in the excretion of conjugated bilirubin. © 1976, The Williams & Wilkins Company. All rights reserved.
Authors & Co-Authors
Miller, D. J.
South Africa, Cape Town
University of Cape Town
Keeton, G. R.
South Africa, Cape Town
University of Cape Town
Webber, Bruce L.
South Africa, Cape Town
University of Cape Town
Saunders, Stuart John
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 120
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/S0016-5085(76)80104-7
ISSN:
00165085