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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Defining the human immunodeficiency virus type 1 transmission genetic bottleneck in a region with multiple circulating subtypes and recombinant forms
Virology, Volume 415, No. 2, Year 2011
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Description
The Mbeya region of Tanzania has a genetically complex HIV epidemic with multiple subtypes and recombinant forms circulating, together with a high frequency of dual infections with more than one subtype. This study aimed to determine whether this impacted the HIV-1 transmission bottleneck. A total of 210 env sequences from 22 participants were generated from recently infected women from Mbeya using the single genome amplification approach. Participants were infected with subtypes C (n= 9), A (n= 4), or D (n= 1), and recombinants AC (n= 4), CD (n= 2), AD (n= 1), or ACD (n= 1). Sixteen participants (73%) were infected with a single variant; five (23%) with multiple variants; and one (4%) was dually infected. Thus the frequency of single variant infections was similar to cohorts located in genetically restricted subtype B or C epidemics, suggesting that multiple circulating subtypes and unique recombinant forms do not have a significant impact on the transmission bottleneck. © 2011 Elsevier Inc.
Authors & Co-Authors
Nofemela, Andile
South Africa, Cape Town
Faculty of Health Sciences
Bandawe, Gama P.
South Africa, Cape Town
Faculty of Health Sciences
Thebus, Ruwayhida
South Africa, Cape Town
Faculty of Health Sciences
Marais, Jinny C.
South Africa, Cape Town
Faculty of Health Sciences
Wood, Natasha T.
South Africa, Cape Town
University of Cape Town
Hoffmann, Oliver
Germany, Munich
Ludwig-maximilians-universität München
Maboko, Leonard L.
Tanzania, Dar es Salaam
Ministry of Health and Social Welfare Dar es Salaam
Höelscher, Michael
Tanzania, Dar es Salaam
Ministry of Health and Social Welfare Dar es Salaam
Germany, Munich
Ludwig-maximilians-universität München
Woodman, Zenda L.
South Africa, Cape Town
University of Cape Town
Williamson, Carolyn
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 15
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/j.virol.2010.12.027
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Tanzania
Participants Gender
Female