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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mother-to-child transmission of HIV-1: Association with malaria prevention, anaemia and placental malaria
HIV Medicine, Volume 9, No. 9, Year 2008
Notification
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Description
Objectives: Malaria infection may impact on mother-to-child transmission (MTCT) of HIV-1. Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique. Methods: A total of 207 HIV-positive Mozambican pregnant women were enrolled in the study as part of a randomized placebo-controlled trial of two-dose sulfadoxine-pyrimethamine (SP) IPTp in women receiving single-dose nevirapine to prevent MTCT of HIV. HIV RNA viral load, maternal anaemia and peripheral and placental malaria were assessed at delivery. Infant HIV status was determined by DNA polymerase chain reaction (PCR) at 1 month of age. Results: There were 19 transmissions of HIV in 153 mother-infant pairs. IPTp with SP did not have a significant impact on MTCT (11.8% in the SP group vs. 13.2% in the placebo group; P = 0.784) or on maternal HIV RNA viral load [16312 (interquartile range {IQR} 4076-69296)HIV-1 RNAcopies/mL in the SP group vs. 18274 (IQR 5471-74104) copies/mL in the placebo group; P = 0.715]. In multivariate analysis, maternal HIV RNA viral load [adjusted odds ratio (AOR) 19.9; 95% confidence interval (CI) 2.3-172; P = 0.006] and anaemia (haematocrit <33%; AOR 7.5; 95% CI 1.7-32.4; P = 0.007) were independent risk factors for MTCT. Placental malaria was associated with a decrease in MTCT (AOR 0.23; 95% CI 0.06-0.89; P = 0.034). Conclusions: IPTp with SP was not associated with a significant impact on MTCT of HIV. Maternal anaemia was an independent risk factor for MTCT. © 2008 British HIV Association.
Authors & Co-Authors
Naniche, Denise
Spain, Barcelona
Instituto de Salud Global de Barcelona
Lahuerta, María
Spain, Barcelona
Instituto de Salud Global de Barcelona
Bardají, Azucena
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Sigaúque, Betuel
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Romagosa, Cleofé
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Berenguera, A.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mandomando, Inácio M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
David, Catarina
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sanz, Sergi M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Aponte, John Jairo
Spain, Barcelona
Instituto de Salud Global de Barcelona
Ordi, J.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Menéndez, Clara
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Statistics
Citations: 29
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1111/j.1468-1293.2008.00626.x
ISSN:
14642662
e-ISSN:
14681293
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Locations
Mozambique
Participants Gender
Female