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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evolutionary history and dynamics of dog rabies virus in western and central Africa
Journal of General Virology, Volume 90, No. 4, Year 2009
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Description
The burden of rabies in Africa is estimated at 24 000 human deaths year-1, almost all of which result from infection with dog rabies viruses (RABV). To investigate the evolutionary dynamics of RABV in western and central Africa, 92 isolates sampled from 27 African countries over 29 years were collected and sequenced. This revealed that RABV currently circulating in dogs in this region fell into a single lineage designated 'Africa 2'. A detailed analysis of the phylogeographical structure of this Africa 2 lineage revealed strong population subdivision at the country level, with only limited movement of virus among localities, including a possible east-to-west spread across Africa. In addition, Bayesian coalescent analysis suggested that the Africa 2 lineage was introduced into this region of Africa only recently (probably <200 years ago), in accordance with the timescale of expanding European colonial influence and urbanization, and then spread relatively slowly, perhaps occupying the entire region in a 100 year period. © 2009 SGM.
Authors & Co-Authors
Talbi, Chiraz
France, Paris
Institut Pasteur, Paris
Holmes, Edward C.
United States, University Park
Pennsylvania State University
de Benedictis, Paola
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Faye, Ousmane C.
Senegal, Dakar
Institut Pasteur de Dakar
Nakouné, Emmanuel Rivalyn
Central African Republic, Bangui
Institut Pasteur de Bangui
Gamatié, Djibo
Niger
Direction Des Laboratoires Vétérinaires
Diarra, Abbas
Mali, Bamako
Laboratoire Central Veterinaire Mail
Elmamy, Bezeid Ould
Mauritania
Centre National D'elevage et de Recherches Vétérinaires
Sow, Adama
Burkina Faso, Ouagadougou
Laboratoire National D'elevage
Adjogoua, Edgard Valery
Cote D'ivoire, Abidjan
Institut Pasteur de Cote-d'ivoire
Sangaré, Oumou
Mali, Bamako
Laboratoire Central Veterinaire Mail
Dundon, William G.
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Capua, Ilaria
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Sall, Amadou Alpha
Senegal, Dakar
Institut Pasteur de Dakar
Bourhy, Hervé
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 106
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1099/vir.0.007765-0
ISSN:
00221317
e-ISSN:
14652099
Study Design
Cross Sectional Study