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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Ethnic differences in serum lipoproteins and their determinants in South African women
Metabolism: Clinical and Experimental, Volume 59, No. 9, Year 2010
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Description
The objective of the study was to characterize ethnic differences in lipid levels and low-density lipoprotein (LDL) particle size and subclasses in black and white South African women and to explore the associations with insulin sensitivity (SI), body composition, and lifestyle factors. Fasting serum lipids and LDL size and subclasses, body composition (dual-energy x-ray absorptiometry), and SI (frequently sampled intravenous glucose tolerance test) were measured in normal-weight (body mass index <25 kg/m 2) black (n = 15) and white (n = 15), and obese (body mass index >30 kg/m2) black (n = 13) and white (n = 13) women. Normal-weight and obese black women had lower triglycerides (0.59 ± 0.09 and 0.77 ± 0.10 vs 0.89 ± 0.09 and 0.93 ± 0.10 mmol/L, P < .05) and high-density lipoprotein cholesterol (1.2 ± 0.1 and 1.1 ± 0.1 vs 1.7 ± 0.1 and 1.6 ± 0.3 mmol/L, P < .01) than white women. The LDL particle size was not different, but obese black women had more LDL subclass IV (17.3% ± 1.0% vs 12.5% ± 1.0%, P < .01). In white women, triglycerides and LDL particle size correlated with SI (P < .01), whereas cholesterol levels correlated with body fat (P < .05). Low socioeconomic status, low dietary protein intake, and injectable contraceptive use were the major determinants of unfavorable lipid profiles in black women. Black women had lower triglyceride and high-density lipoprotein cholesterol levels and more small dense LDL particles than white women. The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, SI and body composition most closely correlated with serum lipids. © 2010 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Goedecke, Julia H.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Utzschneider, Kristina M.
United States, Seattle
University of Washington
Faulenbach, Mirjam V.
United States, Seattle
University of Washington
Rizzo, Manfredi
Italy, Palermo
Università Degli Studi Di Palermo
Berneis, Kaspar K.
Switzerland, Zurich
Universitatsspital Zurich
Switzerland, Zurich
Universität Zürich
Spinas, Giatgen Andreia
Switzerland, Zurich
Universitatsspital Zurich
Dave, Joel A.
South Africa, Cape Town
University of Cape Town
Levitt, Naomi S.
South Africa, Cape Town
University of Cape Town
Lambert, E. Victoria
South Africa, Cape Town
University of Cape Town
Olsson, Tommy
Sweden, Umea
Umeå Universitet
Kahn, Steven E.
United States, Seattle
University of Washington
Statistics
Citations: 82
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.metabol.2009.12.018
ISSN:
00260495
Research Areas
Sexual And Reproductive Health
Participants Gender
Female