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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Xeroderma Pigmentosum: A Retrospective Case Series in Zimbabwe
Journal of Oral and Maxillofacial Surgery, Volume 67, No. 1, Year 2009
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Description
Purpose: To present our experience with the clinical features and management of black African patients with xeroderma pigmentosum (XP). Patients and Methods: Twelve patients with XP were seen over a 25-year period, and were retrospectively reviewed for age, gender, clinical features, treatment, and follow-up. Results: There were 8 females and 4 males with an age range of 3 to 18 years. One patient, the longest survivor, was followed until death at 18 years. Nine patients had the severe form of XP and 3 had the mild form. All patients had early ocular involvement with photophobia and early blindness. Squamous cell carcinoma (SCC) was present on the skin, lip, and tongue in most patients. One patient had ocular surface SCC. There was marked skin photosensitivity. No history of consanguinity was noted in the parents of the patients. Surgery was the treatment modality of choice. Follow-up was poor. Conclusion: XP is uncommon in our black population, and presents in the severe form with SCC as the malignant skin, lip, and tongue lesion. It is common in early childhood with severe photosensitivity, photophobia, and eventual blindness. Follow-up is difficult in our environment. © 2009 American Association of Oral and Maxillofacial Surgeons.
Authors & Co-Authors
Chidzonga, Midion Mapfumo
Zimbabwe, Harare
University of Zimbabwe
Mahomva, Leonard A.
Zimbabwe, Harare
University of Zimbabwe
Makunike-Mutasa, Rudo
Zimbabwe, Harare
University of Zimbabwe
Masanganise, Rangarirai
Zimbabwe, Harare
University of Zimbabwe
Statistics
Citations: 33
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.joms.2007.09.026
ISSN:
02782391
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Zimbabwe
Participants Gender
Female